Regional wall-motion abnormalities on post-stress electrocardiographic-gated technetium-99m sestamibi single-photon emission computed tomography imaging predict cardiac events

Athanasios Kapetanopoulos, Alan W. Ahlberg, Cynthia C. Taub, Deborah M. Katten, Gary V. Heller

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The global left-ventricular (LV) ejection fraction (EF) is a powerful predictor of cardiac death (CD). There are limited data on the prognostic value of regional LV function. We examined the role of visually assessed regional wall motion in risk stratification for future cardiac events. Methods and Results: A prospectively gathered database of 10,336 patients who underwent technetium (Tc)-99m sestamibi-gated single-photon emission computed tomography (SPECT) was analyzed. The summed stress score (SSS) and summed wall-motion score (SWMS) were calculated using a standard 17-segment model. The post-stress EF was generated using QGS software. The follow-up was 90.2% complete over 28.6 ± 16 months. Patients with early (≤60 days) revascularization were censored, leaving 8,767 for analysis. A multivariate analysis demonstrated that abnormal wall motion (SWMS ≥5) was an independent predictor of cardiac death (odds ratio = 1.78, 95% confidence interval = 1.11 to 2.85, P = .016). Among patients with an EF ≥45%, abnormal wall motion was the only gated SPECT variable that independently predicted cardiac death (odds ratio = 1.69, 95% confidence interval = 1.06 to 2.7, P = .028). In patients with an EF ≥45% and reversible perfusion defects, abnormal wall motion predicted an intermediate (2.2%/year) risk for CD, and a high (4.2%/year) risk for the combined endpoint of cardiac death and nonfatal MI. Conclusions: Regional LV function data from gated SPECT provide important prognostic information, and may identify a subgroup of patients with preserved EF and ischemia who are at significant risk for future cardiac events.

Original languageEnglish (US)
Pages (from-to)810-817
Number of pages8
JournalJournal of Nuclear Cardiology
Volume14
Issue number6
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

Technetium Tc 99m Sestamibi
Single-Photon Emission-Computed Tomography
Left Ventricular Function
Odds Ratio
Confidence Intervals
Stroke Volume
Software
Multivariate Analysis
Ischemia
Perfusion
Databases

Keywords

  • diagnostic and prognostic application
  • ejection fraction
  • gated SPECT
  • left ventricular function
  • Sestamibi

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Regional wall-motion abnormalities on post-stress electrocardiographic-gated technetium-99m sestamibi single-photon emission computed tomography imaging predict cardiac events. / Kapetanopoulos, Athanasios; Ahlberg, Alan W.; Taub, Cynthia C.; Katten, Deborah M.; Heller, Gary V.

In: Journal of Nuclear Cardiology, Vol. 14, No. 6, 11.2007, p. 810-817.

Research output: Contribution to journalArticle

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title = "Regional wall-motion abnormalities on post-stress electrocardiographic-gated technetium-99m sestamibi single-photon emission computed tomography imaging predict cardiac events",
abstract = "Background: The global left-ventricular (LV) ejection fraction (EF) is a powerful predictor of cardiac death (CD). There are limited data on the prognostic value of regional LV function. We examined the role of visually assessed regional wall motion in risk stratification for future cardiac events. Methods and Results: A prospectively gathered database of 10,336 patients who underwent technetium (Tc)-99m sestamibi-gated single-photon emission computed tomography (SPECT) was analyzed. The summed stress score (SSS) and summed wall-motion score (SWMS) were calculated using a standard 17-segment model. The post-stress EF was generated using QGS software. The follow-up was 90.2{\%} complete over 28.6 ± 16 months. Patients with early (≤60 days) revascularization were censored, leaving 8,767 for analysis. A multivariate analysis demonstrated that abnormal wall motion (SWMS ≥5) was an independent predictor of cardiac death (odds ratio = 1.78, 95{\%} confidence interval = 1.11 to 2.85, P = .016). Among patients with an EF ≥45{\%}, abnormal wall motion was the only gated SPECT variable that independently predicted cardiac death (odds ratio = 1.69, 95{\%} confidence interval = 1.06 to 2.7, P = .028). In patients with an EF ≥45{\%} and reversible perfusion defects, abnormal wall motion predicted an intermediate (2.2{\%}/year) risk for CD, and a high (4.2{\%}/year) risk for the combined endpoint of cardiac death and nonfatal MI. Conclusions: Regional LV function data from gated SPECT provide important prognostic information, and may identify a subgroup of patients with preserved EF and ischemia who are at significant risk for future cardiac events.",
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AU - Taub, Cynthia C.

AU - Katten, Deborah M.

AU - Heller, Gary V.

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AB - Background: The global left-ventricular (LV) ejection fraction (EF) is a powerful predictor of cardiac death (CD). There are limited data on the prognostic value of regional LV function. We examined the role of visually assessed regional wall motion in risk stratification for future cardiac events. Methods and Results: A prospectively gathered database of 10,336 patients who underwent technetium (Tc)-99m sestamibi-gated single-photon emission computed tomography (SPECT) was analyzed. The summed stress score (SSS) and summed wall-motion score (SWMS) were calculated using a standard 17-segment model. The post-stress EF was generated using QGS software. The follow-up was 90.2% complete over 28.6 ± 16 months. Patients with early (≤60 days) revascularization were censored, leaving 8,767 for analysis. A multivariate analysis demonstrated that abnormal wall motion (SWMS ≥5) was an independent predictor of cardiac death (odds ratio = 1.78, 95% confidence interval = 1.11 to 2.85, P = .016). Among patients with an EF ≥45%, abnormal wall motion was the only gated SPECT variable that independently predicted cardiac death (odds ratio = 1.69, 95% confidence interval = 1.06 to 2.7, P = .028). In patients with an EF ≥45% and reversible perfusion defects, abnormal wall motion predicted an intermediate (2.2%/year) risk for CD, and a high (4.2%/year) risk for the combined endpoint of cardiac death and nonfatal MI. Conclusions: Regional LV function data from gated SPECT provide important prognostic information, and may identify a subgroup of patients with preserved EF and ischemia who are at significant risk for future cardiac events.

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