Regional mapping of the human galactocerebrosidase gene (GALC) to 14q31 by in situ hybridization

L. A. Cannizzaro, Y. Q. Chen, M. A. Rafi, David A. Wenger

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The cDNA for human galactocerebrosidase (GALC) has recently been cloned and expressed. A portion of this cDNA was used for in situ hybridization, and the region of strongest signal corresponded to human chromosome region 14q31. This agrees with recent linkage studies that localized Krabbe disease (globoid cell leukodystrophy) to the same region. This information will be useful in future studies for mapping this gene in animal models of GALC deficiency.

Original languageEnglish (US)
Pages (from-to)244-245
Number of pages2
JournalCytogenetic and Genome Research
Volume66
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

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Galactosylceramidase
Globoid Cell Leukodystrophy
In Situ Hybridization
Complementary DNA
Genes
Chromosome Mapping
Human Chromosomes
Animal Models

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

Cite this

Regional mapping of the human galactocerebrosidase gene (GALC) to 14q31 by in situ hybridization. / Cannizzaro, L. A.; Chen, Y. Q.; Rafi, M. A.; Wenger, David A.

In: Cytogenetic and Genome Research, Vol. 66, No. 4, 1994, p. 244-245.

Research output: Contribution to journalArticle

Cannizzaro, L. A. ; Chen, Y. Q. ; Rafi, M. A. ; Wenger, David A. / Regional mapping of the human galactocerebrosidase gene (GALC) to 14q31 by in situ hybridization. In: Cytogenetic and Genome Research. 1994 ; Vol. 66, No. 4. pp. 244-245.
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