Regional mapping of the human galactocerebrosidase gene (GALC) to 14q31 by in situ hybridization

L. A. Cannizzaro, Y. Q. Chen, M. A. Rafi, David A. Wenger

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The cDNA for human galactocerebrosidase (GALC) has recently been cloned and expressed. A portion of this cDNA was used for in situ hybridization, and the region of strongest signal corresponded to human chromosome region 14q31. This agrees with recent linkage studies that localized Krabbe disease (globoid cell leukodystrophy) to the same region. This information will be useful in future studies for mapping this gene in animal models of GALC deficiency.

Original languageEnglish (US)
Pages (from-to)244-245
Number of pages2
JournalCytogenetic and Genome Research
Volume66
Issue number4
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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