Regional mapping of the human galactocerebrosidase gene (GALC) to 14q31 by in situ hybridization

L. A. Cannizzaro; Y. Q. Chen; M. A. Rafi; David A. Wenger

doi:10.1159/000133703

Regional mapping of the human galactocerebrosidase gene (GALC) to 14q31 by in situ hybridization

L. A. Cannizzaro, Y. Q. Chen, M. A. Rafi, David A. Wenger

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45 Scopus citations

Abstract

The cDNA for human galactocerebrosidase (GALC) has recently been cloned and expressed. A portion of this cDNA was used for in situ hybridization, and the region of strongest signal corresponded to human chromosome region 14q31. This agrees with recent linkage studies that localized Krabbe disease (globoid cell leukodystrophy) to the same region. This information will be useful in future studies for mapping this gene in animal models of GALC deficiency.

Original language	English (US)
Pages (from-to)	244-245
Number of pages	2
Journal	Cytogenetics and Cell Genetics
Volume	66
Issue number	4
DOIs	https://doi.org/10.1159/000133703
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000133703

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abstract = "The cDNA for human galactocerebrosidase (GALC) has recently been cloned and expressed. A portion of this cDNA was used for in situ hybridization, and the region of strongest signal corresponded to human chromosome region 14q31. This agrees with recent linkage studies that localized Krabbe disease (globoid cell leukodystrophy) to the same region. This information will be useful in future studies for mapping this gene in animal models of GALC deficiency.",

author = "Cannizzaro, {L. A.} and Chen, {Y. Q.} and Rafi, {M. A.} and Wenger, {David A.}",

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AU - Cannizzaro, L. A.

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AU - Rafi, M. A.

AU - Wenger, David A.

PY - 1994

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AB - The cDNA for human galactocerebrosidase (GALC) has recently been cloned and expressed. A portion of this cDNA was used for in situ hybridization, and the region of strongest signal corresponded to human chromosome region 14q31. This agrees with recent linkage studies that localized Krabbe disease (globoid cell leukodystrophy) to the same region. This information will be useful in future studies for mapping this gene in animal models of GALC deficiency.

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Regional mapping of the human galactocerebrosidase gene (GALC) to 14q31 by in situ hybridization

Abstract

ASJC Scopus subject areas

UN SDGs

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