Regional glucose metabolism within cortical Brodmann areas in healthy individuals and autistic patients

Erin A. Hazlett, Monte S. Buchsbaum, Pauline Hsieh, M. Mehmet Haznedar, Jimcy Platholi, Elizabeth M. LiCalzi, Charles Cartwright, Eric Hollander

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A new Brodmann area (BA) delineation approach was applied to FDG-PET scans of autistic patients and healthy volunteers (n = 17 in each group) to examine relative glucose metabolism (rGMR) during performance of a verbal memory task. In the frontal lobe, patients had lower rGMR in medial/cingulate regions (BA 32, 24, 25) but not in lateral regions (BA 8-10) compared with healthy controls. Patients had higher rGMR in occipital (BA 19) and parietal regions (BA 39) compared with controls, but there were no group differences in temporal lobe regions. Among controls, better recall and use of the semantic-clustering strategy was associated with greater lateral and medial frontal rGMR, while decreased rGMR in medial-frontal regions was associated with greater perseverative/intrusion errors. Patients failed to show these patterns. Autism patients have dysfunction in some but not all of the key brain regions subserving verbal memory performance, and other regions may be recruited for task performance.

Original languageEnglish (US)
Pages (from-to)115-125
Number of pages11
JournalNeuropsychobiology
Volume49
Issue number3
DOIs
StatePublished - 2004
Externally publishedYes

Fingerprint

Glucose
Temporal Lobe
Parietal Lobe
Gyrus Cinguli
Task Performance and Analysis
Frontal Lobe
Autistic Disorder
Semantics
Positron-Emission Tomography
Cluster Analysis
Healthy Volunteers
Brain

Keywords

  • Autism
  • Brain glucose metabolism
  • Brodmann area
  • Verbal memory performance

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Hazlett, E. A., Buchsbaum, M. S., Hsieh, P., Haznedar, M. M., Platholi, J., LiCalzi, E. M., ... Hollander, E. (2004). Regional glucose metabolism within cortical Brodmann areas in healthy individuals and autistic patients. Neuropsychobiology, 49(3), 115-125. https://doi.org/10.1159/000076719

Regional glucose metabolism within cortical Brodmann areas in healthy individuals and autistic patients. / Hazlett, Erin A.; Buchsbaum, Monte S.; Hsieh, Pauline; Haznedar, M. Mehmet; Platholi, Jimcy; LiCalzi, Elizabeth M.; Cartwright, Charles; Hollander, Eric.

In: Neuropsychobiology, Vol. 49, No. 3, 2004, p. 115-125.

Research output: Contribution to journalArticle

Hazlett, EA, Buchsbaum, MS, Hsieh, P, Haznedar, MM, Platholi, J, LiCalzi, EM, Cartwright, C & Hollander, E 2004, 'Regional glucose metabolism within cortical Brodmann areas in healthy individuals and autistic patients', Neuropsychobiology, vol. 49, no. 3, pp. 115-125. https://doi.org/10.1159/000076719
Hazlett, Erin A. ; Buchsbaum, Monte S. ; Hsieh, Pauline ; Haznedar, M. Mehmet ; Platholi, Jimcy ; LiCalzi, Elizabeth M. ; Cartwright, Charles ; Hollander, Eric. / Regional glucose metabolism within cortical Brodmann areas in healthy individuals and autistic patients. In: Neuropsychobiology. 2004 ; Vol. 49, No. 3. pp. 115-125.
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