Regional differences in concentrations of regulatory peptides in human colon mucosal biopsy

J. Calam, M. A. Ghatei, J. Domin, T. E. Adrian, M. Myszor, Sanjeev Gupta, C. Tait, S. R. Bloom

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The study was undertaken to examine regional differences in the concentrations of five regulatory peptides in the human colonic mucosa. Biopsies were obtained during routine colonoscopy from 33 patients whose colonic mucosa was macroscopically and histologically normal. Regulatory peptides were extracted, and measured by specific radioimmunoassays. Concentrations of three peptides that are present predominantly in endocrine cells within colonic mucosa increased significantly towards the rectum: Mean concentrations of peptide YY, enteroglucagon, and somatostatin were about three times greater in the rectum than in the cecum. However, concentrations of two peptides that are present in mucosal nerve fibers diminished significantly towards the rectum: Mean rectal concentrations of vasoactive intestinal peptide and peptide histidine methionine were both about 0.6 of mean cecal concentrations. Concentrations of all five peptides were lower in biopsies taken from colonic polyps than in normal colonic mucosa. Regional differences in colonic mucosal concentrations of regulatory peptides probably reflect differences in the physiological functions of different parts of the colon.

Original languageEnglish (US)
Pages (from-to)1193-1198
Number of pages6
JournalDigestive Diseases and Sciences
Volume34
Issue number8
DOIs
StatePublished - Aug 1989
Externally publishedYes

Fingerprint

Colon
Biopsy
Peptides
Mucous Membrane
Rectum
Peptide PHI
Glucagon-Like Peptides
Colonic Polyps
Peptide YY
Endocrine Cells
Cecum
Vasoactive Intestinal Peptide
Colonoscopy
Somatostatin
Nerve Fibers
Radioimmunoassay

Keywords

  • colon
  • colonic polyps
  • enteroglucagon
  • somatostatin
  • vasoactive intestinal peptide

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Regional differences in concentrations of regulatory peptides in human colon mucosal biopsy. / Calam, J.; Ghatei, M. A.; Domin, J.; Adrian, T. E.; Myszor, M.; Gupta, Sanjeev; Tait, C.; Bloom, S. R.

In: Digestive Diseases and Sciences, Vol. 34, No. 8, 08.1989, p. 1193-1198.

Research output: Contribution to journalArticle

Calam, J, Ghatei, MA, Domin, J, Adrian, TE, Myszor, M, Gupta, S, Tait, C & Bloom, SR 1989, 'Regional differences in concentrations of regulatory peptides in human colon mucosal biopsy', Digestive Diseases and Sciences, vol. 34, no. 8, pp. 1193-1198. https://doi.org/10.1007/BF01537267
Calam, J. ; Ghatei, M. A. ; Domin, J. ; Adrian, T. E. ; Myszor, M. ; Gupta, Sanjeev ; Tait, C. ; Bloom, S. R. / Regional differences in concentrations of regulatory peptides in human colon mucosal biopsy. In: Digestive Diseases and Sciences. 1989 ; Vol. 34, No. 8. pp. 1193-1198.
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