Regional chromosome localization of human papillomavirus intergration sites near fragile sites, oncogenes, and cancer chromosome breakpoints

Linda A. Cannizzaro, Matthias Dürst, Michael J. Mendez, Barbara K. Hecht, Frederick Hecht

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

The integration sites of human papillomavirus (HPV) DNA within the cervical carcinoma cell line C4-I and a primary cervical tumor were mapped by in situ hybridization. Cloned cellular sequences flanking the integrated viral DNA were used as probes. For the cell line, the viral integration site was mapped to chromosome region 8q21-q22.3, while in the primary tumor chromosome band 3p21 was the target for integration. The HPV DNA integration appears to occur in the vicinity of fragile sites, oncogenes, and chromosome breakpoints that are characteristic of hematologic malignancies and solid tumors. The integration of HPV may thus promote chromosome changes in cancer cells.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume33
Issue number1
DOIs
StatePublished - Jul 1 1988
Externally publishedYes

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Chromosome Breakpoints
Human Chromosomes
Oncogenes
Chromosomes
Neoplasms
Virus Integration
Cell Line
DNA
Viral DNA
Hematologic Neoplasms
In Situ Hybridization
Carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Regional chromosome localization of human papillomavirus intergration sites near fragile sites, oncogenes, and cancer chromosome breakpoints. / Cannizzaro, Linda A.; Dürst, Matthias; Mendez, Michael J.; Hecht, Barbara K.; Hecht, Frederick.

In: Cancer Genetics and Cytogenetics, Vol. 33, No. 1, 01.07.1988, p. 93-98.

Research output: Contribution to journalArticle

Cannizzaro, Linda A. ; Dürst, Matthias ; Mendez, Michael J. ; Hecht, Barbara K. ; Hecht, Frederick. / Regional chromosome localization of human papillomavirus intergration sites near fragile sites, oncogenes, and cancer chromosome breakpoints. In: Cancer Genetics and Cytogenetics. 1988 ; Vol. 33, No. 1. pp. 93-98.
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