Reference values of urinary neutrophil gelatinase-Associated lipocalin in very low birth weight infants

Trang K. Huynh, David A. Bateman, Elvira Parravicini, John M. Lorenz, Sheri L. Nemerofsky, Meghan E. Sise, Teresa M. Bowman, Elena Polesana, Jonathan M. Barasch

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58 Citations (Scopus)

Abstract

In very low birth weight (VLBW) infants, acute renal impairment (ARI) is common, but there is no consensus about criteria for its diagnosis. Neutrophil gelatinase-associated lipocalin (NGAL) is an early and sensitive indicator of renal impairment in experimental animals, children, and adults. Urinary NGAL (UNGAL) is detectable in VLBW infants; however, there is no reference range in this population. The objective of this study is to define the reference range for UNGAL in VLBW infants with no risk factors for acute renal impairment. UNGAL concentration was determined in urine samples collected from day of life (DOL) 4 through DOL 30 in 50 newborns with uncomplicated clinical courses, selected from a total of 145 prospectively enrolled appropriate for gestational age inborn VLBW premature infants. The birth weight and gestational age ranges were 790-1490 g and 26-33 wk, respectively. The median, 95th and 99th percentiles, and range of pooled UNGAL values were 5 ng/mL, 50 ng/mL, 120 ng/mL, and 2-150 ng/mL, respectively. Greater variability and higher quantile levels of UNGAL were observed in females versus males. In conclusion, a reference range for UNGAL in VLBW infants, similar to that in children and adults, has been established.

Original languageEnglish (US)
Pages (from-to)528-532
Number of pages5
JournalPediatric Research
Volume66
Issue number5
DOIs
StatePublished - Nov 2009

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Very Low Birth Weight Infant
Reference Values
Kidney
Gestational Age
Birth Weight
Premature Infants
Lipocalin-2
Urine
Newborn Infant
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Reference values of urinary neutrophil gelatinase-Associated lipocalin in very low birth weight infants. / Huynh, Trang K.; Bateman, David A.; Parravicini, Elvira; Lorenz, John M.; Nemerofsky, Sheri L.; Sise, Meghan E.; Bowman, Teresa M.; Polesana, Elena; Barasch, Jonathan M.

In: Pediatric Research, Vol. 66, No. 5, 11.2009, p. 528-532.

Research output: Contribution to journalArticle

Huynh, TK, Bateman, DA, Parravicini, E, Lorenz, JM, Nemerofsky, SL, Sise, ME, Bowman, TM, Polesana, E & Barasch, JM 2009, 'Reference values of urinary neutrophil gelatinase-Associated lipocalin in very low birth weight infants', Pediatric Research, vol. 66, no. 5, pp. 528-532. https://doi.org/10.1203/PDR.0b013e3181baa3dd
Huynh, Trang K. ; Bateman, David A. ; Parravicini, Elvira ; Lorenz, John M. ; Nemerofsky, Sheri L. ; Sise, Meghan E. ; Bowman, Teresa M. ; Polesana, Elena ; Barasch, Jonathan M. / Reference values of urinary neutrophil gelatinase-Associated lipocalin in very low birth weight infants. In: Pediatric Research. 2009 ; Vol. 66, No. 5. pp. 528-532.
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