Reference range of urinary neutrophil gelatinase-associated lipocalin in very low-birth-weight infants: Preliminary data

Elvira Parravicini, John M. Lorenz, Sheri L. Nemerofsky, Matthew O'Rourke, Jonathan Barasch, David Bateman

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We sought to determine the reference range for urinary neutrophil gelatinase-associated lipocalin (UNGAL) in very low-birth-weight (VLBW) infants with uncomplicated clinical courses. Samples of urine from 53 VLBW infants between 3 and 28 days of life were prospectively collected weekly for measurement of UNGAL. A subset of 22 infants with uncomplicated medical courses without risk factors for renal impairment was selected for study. Mean ± standard deviation and range for birth weight and gestational age of study infants were 1156 ± 191, 790 to 1440 g and 29 ± 2, 27 to 33 weeks, respectively. The 95th and 99th percentiles for UNGAL concentration from this group of infants were 25 ng/mL and 75 ng/mL, respectively. Bootstrapped mean 95th and 99th percentile values and their standard errors and 95 percent confidence intervals in ng/mL were 33.1 ± 13.0 (7.7, 58.6) and 67.5 ± 15.1 (37.9, 97.1), respectively. These values fall within the adult reference range. UNGAL values were stable across the ranges of gestational and postnatal age of the study infants. A preliminary reference range for UNGAL in VLBW infants has been established. Further investigation with more frequent urine collections in a larger population of VLBW infants that includes those with birth weights < 750 g and gestational ages < 27 weeks is necessary to confirm this reference range.

Original languageEnglish (US)
Pages (from-to)437-440
Number of pages4
JournalAmerican Journal of Perinatology
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 1 2009
Externally publishedYes

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Keywords

  • Acute renal failure
  • Neutrophil gelatinase-associated lipocalin
  • Renal impairment
  • Very low-birth-weight infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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