Reduced connexin 43 expression in high grade, human prostatic adenocarcinoma cells

Harold Tsai, John Werber, Michael O. Davia, Morris Edelman, Kathryn E. Tanaka, Arnold Melman, George J. Christ, Jan Geliebter

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

Gap junction-mediated communication is required for normal cellular growth and differentiation. As cancer is thought to be a manifestation of the breakdown of cell-cell communication, with tile concomitant loss of growth control, it would be expected that alterations in the primary structure, processing, oligomerization or trafficking of connexin (cxn) molecules would have a profound effect on the neoplastic process. Here we a present a preliminary immunohistochemical and molecular analysis of cxn 43 expression in prostatic epithelial cells from resected human tissue. Our data indicate that benign prostatic epithelial cells express cxn 43 protein, but that this expression is diminished in more advanced, anaplastic cancer cells. These data suggest that decreased connexin expression is not involved in the initiation of prostate cancer, but rather occurs during the progression of the disease.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume227
Issue number1
DOIs
StatePublished - Oct 3 1996

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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