TY - JOUR
T1 - Reduced connexin 43 expression in high grade, human prostatic adenocarcinoma cells
AU - Tsai, Harold
AU - Werber, John
AU - Davia, Michael O.
AU - Edelman, Morris
AU - Tanaka, Kathryn E.
AU - Melman, Arnold
AU - Christ, George J.
AU - Geliebter, Jan
PY - 1996/10/3
Y1 - 1996/10/3
N2 - Gap junction-mediated communication is required for normal cellular growth and differentiation. As cancer is thought to be a manifestation of the breakdown of cell-cell communication, with tile concomitant loss of growth control, it would be expected that alterations in the primary structure, processing, oligomerization or trafficking of connexin (cxn) molecules would have a profound effect on the neoplastic process. Here we a present a preliminary immunohistochemical and molecular analysis of cxn 43 expression in prostatic epithelial cells from resected human tissue. Our data indicate that benign prostatic epithelial cells express cxn 43 protein, but that this expression is diminished in more advanced, anaplastic cancer cells. These data suggest that decreased connexin expression is not involved in the initiation of prostate cancer, but rather occurs during the progression of the disease.
AB - Gap junction-mediated communication is required for normal cellular growth and differentiation. As cancer is thought to be a manifestation of the breakdown of cell-cell communication, with tile concomitant loss of growth control, it would be expected that alterations in the primary structure, processing, oligomerization or trafficking of connexin (cxn) molecules would have a profound effect on the neoplastic process. Here we a present a preliminary immunohistochemical and molecular analysis of cxn 43 expression in prostatic epithelial cells from resected human tissue. Our data indicate that benign prostatic epithelial cells express cxn 43 protein, but that this expression is diminished in more advanced, anaplastic cancer cells. These data suggest that decreased connexin expression is not involved in the initiation of prostate cancer, but rather occurs during the progression of the disease.
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U2 - 10.1006/bbrc.1996.1468
DO - 10.1006/bbrc.1996.1468
M3 - Article
C2 - 8858104
AN - SCOPUS:0030567963
SN - 0006-291X
VL - 227
SP - 64
EP - 69
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -