TY - JOUR
T1 - Redox toxicology of environmental chemicals causing oxidative stress
AU - Zheng, Fuli
AU - Gonçalves, Filipe Marques
AU - Abiko, Yumi
AU - Li, Huangyuan
AU - Kumagai, Yoshito
AU - Aschner, Michael
N1 - Funding Information:
This work is supported by the National Institutes of Health [grant numbers R01ES07331 , R01ES10563 ], the National Natural Science Foundation of China [grant number 81573195 , 81903352 , 81973083 ], the Joint Funds for the Innovation of Science and Technology, Fujian province [grant number 2017Y9105 ] and grant-in-aids for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan [grant number 18H05293 , 17K15489 ].
Publisher Copyright:
© 2020 The Authors
PY - 2020/7
Y1 - 2020/7
N2 - Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regulations are also reviewed.
AB - Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regulations are also reviewed.
KW - Air pollutants
KW - Epigenetic modifications
KW - Heavy metals
KW - NRF2
KW - Pesticides
KW - Redox signaling pathways
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U2 - 10.1016/j.redox.2020.101475
DO - 10.1016/j.redox.2020.101475
M3 - Review article
C2 - 32336668
AN - SCOPUS:85083570736
SN - 2213-2317
VL - 34
JO - Redox Biology
JF - Redox Biology
M1 - 101475
ER -
