Redox Potential of Iron-Bleomycin

Dean L. Melnyk, Susan Band Horwitz, Jack Peisach

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The oxidation-reduction potential of the iron complex of bleomycin, an antitumor agent that cleaves deoxyribonucleic acid (DNA), was measured at 25 °C, pH 7.0, by using both a microcoulometric and an optical absorption method. A value of 129 ± 12 mV was obtained vs. the standard hydrogen electrode for a single-electron process. Thus, ferrous bleomycin, the active form of the antitumor drug, can be regenerated under physiological conditions from ferric bleomycin, a product of the DNA cleavage reaction.

Original languageEnglish (US)
Pages (from-to)5327-5331
Number of pages5
JournalBiochemistry
Volume20
Issue number18
DOIs
Publication statusPublished - Sep 1981

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ASJC Scopus subject areas

  • Biochemistry

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