Redox Potential of Iron-Bleomycin

Dean L. Melnyk, Susan Band Horwitz, Jack Peisach

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The oxidation-reduction potential of the iron complex of bleomycin, an antitumor agent that cleaves deoxyribonucleic acid (DNA), was measured at 25 °C, pH 7.0, by using both a microcoulometric and an optical absorption method. A value of 129 ± 12 mV was obtained vs. the standard hydrogen electrode for a single-electron process. Thus, ferrous bleomycin, the active form of the antitumor drug, can be regenerated under physiological conditions from ferric bleomycin, a product of the DNA cleavage reaction.

Original languageEnglish (US)
Pages (from-to)5327-5331
Number of pages5
Issue number18
StatePublished - Sep 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry


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