Redox potential of iron-bleomycin

Dean L. Melnyk, Susan Band Horwitz, Jack Peisach

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The oxidation-reduction potential of the iron complex of bleomycin, an antitumor agent that cleaves deoxyribonucleic acid (DNA), was measured at 25°C, pH 7.0, by using both a microcoulometric and an optical absorption method. A value of 129 ± 12 mV was obtained vs. the standard hydrogen electrode for a single-electron process. Thus, ferrous bleomycin, the active form of the antitumor drug, can be regenerated under physiological conditions from ferric bleomycin, a product of the DNA cleavage reaction.

Original languageEnglish (US)
Pages (from-to)5327-5331
Number of pages5
JournalBiochemistry
Volume20
Issue number18
StatePublished - 1981

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Bleomycin
Antineoplastic Agents
Oxidation-Reduction
DNA
Light absorption
Hydrogen
Electrodes
Iron
Electrons
iron bleomycin

ASJC Scopus subject areas

  • Biochemistry

Cite this

Melnyk, D. L., Band Horwitz, S., & Peisach, J. (1981). Redox potential of iron-bleomycin. Biochemistry, 20(18), 5327-5331.

Redox potential of iron-bleomycin. / Melnyk, Dean L.; Band Horwitz, Susan; Peisach, Jack.

In: Biochemistry, Vol. 20, No. 18, 1981, p. 5327-5331.

Research output: Contribution to journalArticle

Melnyk, DL, Band Horwitz, S & Peisach, J 1981, 'Redox potential of iron-bleomycin', Biochemistry, vol. 20, no. 18, pp. 5327-5331.
Melnyk DL, Band Horwitz S, Peisach J. Redox potential of iron-bleomycin. Biochemistry. 1981;20(18):5327-5331.
Melnyk, Dean L. ; Band Horwitz, Susan ; Peisach, Jack. / Redox potential of iron-bleomycin. In: Biochemistry. 1981 ; Vol. 20, No. 18. pp. 5327-5331.
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