Abstract
The oxidation-reduction potential of the iron complex of bleomycin, an antitumor agent that cleaves deoxyribonucleic acid (DNA), was measured at 25 °C, pH 7.0, by using both a microcoulometric and an optical absorption method. A value of 129 ± 12 mV was obtained vs. the standard hydrogen electrode for a single-electron process. Thus, ferrous bleomycin, the active form of the antitumor drug, can be regenerated under physiological conditions from ferric bleomycin, a product of the DNA cleavage reaction.
Original language | English (US) |
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Pages (from-to) | 5327-5331 |
Number of pages | 5 |
Journal | Biochemistry |
Volume | 20 |
Issue number | 18 |
DOIs | |
State | Published - Sep 1981 |
ASJC Scopus subject areas
- Biochemistry