Red blood cells from pluripotent stem cells for use in transfusion

Joanne C. Mountford, Emmanuel Olivier, Niove E. Jordanides, Paul De Sousa, Marc L. Turner

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

The use of donated red blood cells in transfusion is a well-established cellular therapy. However, problems including insufficient supply, transfusion-transmitted infections and the need for immunological matching hamper even in the best services. These issues may be eliminated by using pluripotent stem cells to generate universal donor group O, Rhesus D-negative red blood cells. Human embryonic stem cells can be maintained and expanded indefinitely and can, therefore, produce the very large cell numbers required for this application. Red blood cell production is also an attractive goal for pluripotent stem cell-derived therapeutics because it is a well-characterized single cell suspension, lacking nucleated cells and with a low expression of HLA molecules. Much progress has been made; however, a number of challenges remain including scale-up, clinical effectiveness and product safety.

Original languageEnglish (US)
Pages (from-to)411-423
Number of pages13
JournalRegenerative Medicine
Volume5
Issue number3
DOIs
Publication statusPublished - May 2010
Externally publishedYes

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Keywords

  • Blood transfusion
  • Cell therapy
  • Current good manufacturing practice
  • Pluripotent stem cell
  • Red blood cell

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

Cite this

Mountford, J. C., Olivier, E., Jordanides, N. E., De Sousa, P., & Turner, M. L. (2010). Red blood cells from pluripotent stem cells for use in transfusion. Regenerative Medicine, 5(3), 411-423. https://doi.org/10.2217/rme.10.22