Red blood cell fatty acids and biomarkers of inflammation: A cross-sectional study in a community-based cohort

Joao Daniel T. Fontes, Faisal Rahman, Sean Lacey, Martin G. Larson, Ramachandran S. Vasan, Emelia J. Benjamin, William S. Harris, Sander J. Robins

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Introduction: Inflammation and inflammatory biomarkers have emerged as integral components and predictors of incident cardiovascular (CV) disease. Omega-3 fatty acids, particularly eicosapentaenoic and docosahexaenoic acids (EPA and DHA) have anti-inflammatory properties, and have been variably associated with lower blood pressure, favorable blood lipid changes, and reduced CV events. Methods and results: We examined the cross-sectional association of red blood cell (RBC) fatty acids, representative of body membrane fatty acid composition, with 10 biomarkers active in multiple inflammatory pathways in 2724 participants (mean age 66±9 years, 54% women, 8% minorities) from the Framingham Offspring and minority Omni Cohorts. After multivariable adjustment, the RBC EPA and DHA content was inversely correlated (all P≤0.001) with 8 biomarkers: urinary isoprostanes (r=-0.16); and soluble interleukin-6 (r=-0.10); C-reactive protein (r=-0.08); tumor necrosis factor receptor 2 (r=-0.08); intercellular adhesion molecule-1 (r=-0.08); P-selectin (r=-0.06); lipoprotein-associated phospholipase-A2 mass (r=-0.11) and activity (r=-0.08). The correlations for monocyte chemoattractant protein-1 was-0.05, P=0.006 and osteoprotegerin (r=-0.06, P=0.002) were only nominally significant. Conclusion: In our large community-based study, we observed modest inverse associations between several types of inflammatory biomarkers with RBC omega-3 fatty acid levels. Our findings are consistent with the hypothesis that omega-3 fatty acids have anti-inflammatory properties.

Original languageEnglish (US)
Pages (from-to)431-436
Number of pages6
JournalAtherosclerosis
Volume240
Issue number2
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
Fatty Acids
Cross-Sectional Studies
Erythrocytes
Biomarkers
Inflammation
Eicosapentaenoic Acid
Docosahexaenoic Acids
Anti-Inflammatory Agents
1-Alkyl-2-acetylglycerophosphocholine Esterase
Receptors, Tumor Necrosis Factor, Type II
Isoprostanes
Osteoprotegerin
P-Selectin
Chemokine CCL2
Intercellular Adhesion Molecule-1
C-Reactive Protein
Interleukin-6
Cardiovascular Diseases
Blood Pressure

Keywords

  • Biomarkers
  • Cross-sectional study
  • Inflammation
  • Omega-3 fatty acids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Red blood cell fatty acids and biomarkers of inflammation : A cross-sectional study in a community-based cohort. / Fontes, Joao Daniel T.; Rahman, Faisal; Lacey, Sean; Larson, Martin G.; Vasan, Ramachandran S.; Benjamin, Emelia J.; Harris, William S.; Robins, Sander J.

In: Atherosclerosis, Vol. 240, No. 2, 01.06.2015, p. 431-436.

Research output: Contribution to journalArticle

Fontes, JDT, Rahman, F, Lacey, S, Larson, MG, Vasan, RS, Benjamin, EJ, Harris, WS & Robins, SJ 2015, 'Red blood cell fatty acids and biomarkers of inflammation: A cross-sectional study in a community-based cohort', Atherosclerosis, vol. 240, no. 2, pp. 431-436. https://doi.org/10.1016/j.atherosclerosis.2015.03.043
Fontes, Joao Daniel T. ; Rahman, Faisal ; Lacey, Sean ; Larson, Martin G. ; Vasan, Ramachandran S. ; Benjamin, Emelia J. ; Harris, William S. ; Robins, Sander J. / Red blood cell fatty acids and biomarkers of inflammation : A cross-sectional study in a community-based cohort. In: Atherosclerosis. 2015 ; Vol. 240, No. 2. pp. 431-436.
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AU - Fontes, Joao Daniel T.

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AU - Lacey, Sean

AU - Larson, Martin G.

AU - Vasan, Ramachandran S.

AU - Benjamin, Emelia J.

AU - Harris, William S.

AU - Robins, Sander J.

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N2 - Introduction: Inflammation and inflammatory biomarkers have emerged as integral components and predictors of incident cardiovascular (CV) disease. Omega-3 fatty acids, particularly eicosapentaenoic and docosahexaenoic acids (EPA and DHA) have anti-inflammatory properties, and have been variably associated with lower blood pressure, favorable blood lipid changes, and reduced CV events. Methods and results: We examined the cross-sectional association of red blood cell (RBC) fatty acids, representative of body membrane fatty acid composition, with 10 biomarkers active in multiple inflammatory pathways in 2724 participants (mean age 66±9 years, 54% women, 8% minorities) from the Framingham Offspring and minority Omni Cohorts. After multivariable adjustment, the RBC EPA and DHA content was inversely correlated (all P≤0.001) with 8 biomarkers: urinary isoprostanes (r=-0.16); and soluble interleukin-6 (r=-0.10); C-reactive protein (r=-0.08); tumor necrosis factor receptor 2 (r=-0.08); intercellular adhesion molecule-1 (r=-0.08); P-selectin (r=-0.06); lipoprotein-associated phospholipase-A2 mass (r=-0.11) and activity (r=-0.08). The correlations for monocyte chemoattractant protein-1 was-0.05, P=0.006 and osteoprotegerin (r=-0.06, P=0.002) were only nominally significant. Conclusion: In our large community-based study, we observed modest inverse associations between several types of inflammatory biomarkers with RBC omega-3 fatty acid levels. Our findings are consistent with the hypothesis that omega-3 fatty acids have anti-inflammatory properties.

AB - Introduction: Inflammation and inflammatory biomarkers have emerged as integral components and predictors of incident cardiovascular (CV) disease. Omega-3 fatty acids, particularly eicosapentaenoic and docosahexaenoic acids (EPA and DHA) have anti-inflammatory properties, and have been variably associated with lower blood pressure, favorable blood lipid changes, and reduced CV events. Methods and results: We examined the cross-sectional association of red blood cell (RBC) fatty acids, representative of body membrane fatty acid composition, with 10 biomarkers active in multiple inflammatory pathways in 2724 participants (mean age 66±9 years, 54% women, 8% minorities) from the Framingham Offspring and minority Omni Cohorts. After multivariable adjustment, the RBC EPA and DHA content was inversely correlated (all P≤0.001) with 8 biomarkers: urinary isoprostanes (r=-0.16); and soluble interleukin-6 (r=-0.10); C-reactive protein (r=-0.08); tumor necrosis factor receptor 2 (r=-0.08); intercellular adhesion molecule-1 (r=-0.08); P-selectin (r=-0.06); lipoprotein-associated phospholipase-A2 mass (r=-0.11) and activity (r=-0.08). The correlations for monocyte chemoattractant protein-1 was-0.05, P=0.006 and osteoprotegerin (r=-0.06, P=0.002) were only nominally significant. Conclusion: In our large community-based study, we observed modest inverse associations between several types of inflammatory biomarkers with RBC omega-3 fatty acid levels. Our findings are consistent with the hypothesis that omega-3 fatty acids have anti-inflammatory properties.

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