Recurrent respiratory infections and gastroenteritis associated with failure to thrive in a 17-month-old infant

M. Charytan, R. Rojas, Arye Rubinstein

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Our patient's clinical/immunologic course was consistent with an acquired immunodeficiency syndrome (AIDS) of infancy. The pertinent risk factors present include a maternal history of multiple sexual partners and intravenous drug abuse before and during pregnancy. As in the adult form, an initial prodromal phase is followed by a progressive severe immunodeficiency, and ultimately by opportunistic infections. Common clinical features of AIDS in children include low birth weight, failure to thrive, generalized lymphadenopathy, hepatosplenomegaly, parotitis, chronic diarrhea, recurrent bacterial and viral infections, and oropharyngeal thrush. Opportunistic infections with pneumocystis carinii, mycobacterium avium intracellularae, and CMV follow later on. In our experience, pulmonary disease is a prominent early feature. It can present as recurrent lobar, alveolar infiltrates, responsive to intravenous antibiotics such as ampicillin. Later on, chronic bilateral interstitial infiltrates develop and are associated with progressive hypoxemia and digital clubbing. Lung biopsy has documented the presence of a nodular and/or diffuse lymphotic infiltration in many of these patients. Others have presented with acute respiratory distress from pneumonitis with P. carinii and disseminated CMV.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalAnnals of Allergy
Volume53
Issue number3
StatePublished - 1984

Fingerprint

Pneumocystis carinii
Failure to Thrive
Sexual Partners
Opportunistic Infections
Gastroenteritis
Respiratory Tract Infections
Acquired Immunodeficiency Syndrome
Intravenous Substance Abuse
Parotitis
Oral Candidiasis
Mycobacterium avium
Low Birth Weight Infant
Virus Diseases
Ampicillin
Bacterial Infections
Lung Diseases
Diarrhea
Pneumonia
Mothers
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Recurrent respiratory infections and gastroenteritis associated with failure to thrive in a 17-month-old infant. / Charytan, M.; Rojas, R.; Rubinstein, Arye.

In: Annals of Allergy, Vol. 53, No. 3, 1984, p. 215-222.

Research output: Contribution to journalArticle

@article{914b882d3d87473b9c228d459bd8b9b0,
title = "Recurrent respiratory infections and gastroenteritis associated with failure to thrive in a 17-month-old infant",
abstract = "Our patient's clinical/immunologic course was consistent with an acquired immunodeficiency syndrome (AIDS) of infancy. The pertinent risk factors present include a maternal history of multiple sexual partners and intravenous drug abuse before and during pregnancy. As in the adult form, an initial prodromal phase is followed by a progressive severe immunodeficiency, and ultimately by opportunistic infections. Common clinical features of AIDS in children include low birth weight, failure to thrive, generalized lymphadenopathy, hepatosplenomegaly, parotitis, chronic diarrhea, recurrent bacterial and viral infections, and oropharyngeal thrush. Opportunistic infections with pneumocystis carinii, mycobacterium avium intracellularae, and CMV follow later on. In our experience, pulmonary disease is a prominent early feature. It can present as recurrent lobar, alveolar infiltrates, responsive to intravenous antibiotics such as ampicillin. Later on, chronic bilateral interstitial infiltrates develop and are associated with progressive hypoxemia and digital clubbing. Lung biopsy has documented the presence of a nodular and/or diffuse lymphotic infiltration in many of these patients. Others have presented with acute respiratory distress from pneumonitis with P. carinii and disseminated CMV.",
author = "M. Charytan and R. Rojas and Arye Rubinstein",
year = "1984",
language = "English (US)",
volume = "53",
pages = "215--222",
journal = "Annals of Allergy, Asthma and Immunology",
issn = "1081-1206",
publisher = "American College of Allergy, Asthma and Immunology",
number = "3",

}

TY - JOUR

T1 - Recurrent respiratory infections and gastroenteritis associated with failure to thrive in a 17-month-old infant

AU - Charytan, M.

AU - Rojas, R.

AU - Rubinstein, Arye

PY - 1984

Y1 - 1984

N2 - Our patient's clinical/immunologic course was consistent with an acquired immunodeficiency syndrome (AIDS) of infancy. The pertinent risk factors present include a maternal history of multiple sexual partners and intravenous drug abuse before and during pregnancy. As in the adult form, an initial prodromal phase is followed by a progressive severe immunodeficiency, and ultimately by opportunistic infections. Common clinical features of AIDS in children include low birth weight, failure to thrive, generalized lymphadenopathy, hepatosplenomegaly, parotitis, chronic diarrhea, recurrent bacterial and viral infections, and oropharyngeal thrush. Opportunistic infections with pneumocystis carinii, mycobacterium avium intracellularae, and CMV follow later on. In our experience, pulmonary disease is a prominent early feature. It can present as recurrent lobar, alveolar infiltrates, responsive to intravenous antibiotics such as ampicillin. Later on, chronic bilateral interstitial infiltrates develop and are associated with progressive hypoxemia and digital clubbing. Lung biopsy has documented the presence of a nodular and/or diffuse lymphotic infiltration in many of these patients. Others have presented with acute respiratory distress from pneumonitis with P. carinii and disseminated CMV.

AB - Our patient's clinical/immunologic course was consistent with an acquired immunodeficiency syndrome (AIDS) of infancy. The pertinent risk factors present include a maternal history of multiple sexual partners and intravenous drug abuse before and during pregnancy. As in the adult form, an initial prodromal phase is followed by a progressive severe immunodeficiency, and ultimately by opportunistic infections. Common clinical features of AIDS in children include low birth weight, failure to thrive, generalized lymphadenopathy, hepatosplenomegaly, parotitis, chronic diarrhea, recurrent bacterial and viral infections, and oropharyngeal thrush. Opportunistic infections with pneumocystis carinii, mycobacterium avium intracellularae, and CMV follow later on. In our experience, pulmonary disease is a prominent early feature. It can present as recurrent lobar, alveolar infiltrates, responsive to intravenous antibiotics such as ampicillin. Later on, chronic bilateral interstitial infiltrates develop and are associated with progressive hypoxemia and digital clubbing. Lung biopsy has documented the presence of a nodular and/or diffuse lymphotic infiltration in many of these patients. Others have presented with acute respiratory distress from pneumonitis with P. carinii and disseminated CMV.

UR - http://www.scopus.com/inward/record.url?scp=0021637190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021637190&partnerID=8YFLogxK

M3 - Article

C2 - 6089615

AN - SCOPUS:0021637190

VL - 53

SP - 215

EP - 222

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

SN - 1081-1206

IS - 3

ER -