Recurrent hepatic sarcoidosis post-liver transplantation manifesting with severe hypercalcemia: A case report and review of the literature

Cem Cengiz, Manuel Rodriguez-Davalos, Graciela de Boccardo, M. Isabel Fiel, Gonzalo Rodriguez-Laiz, Mark Kovacevic, Sukru Emre, Thomas Schiano

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Sarcoidosis is a systemic granulomatous disease primarily involving the lungs, lymph nodes, skin, eyes and nervous system; liver involvement is asymptomatic in most cases. However, once the patient develops clinical symptoms liver disease is usually progressive and may necessitate orthotopic liver transplantation. There are a few reports of asymptomatic recurrent sarcoidosis developing within the liver allograft. We report a case of early recurrence of sarcoidosis in the liver allograft diagnosed on biopsy in a patient who presented with severe hypercalcemia, kidney dysfunction, and increase in size of abdominal lymph nodes. The liver chemistry tests were within normal limits. The patient responded well to steroid treatment by normalizing serum calcium and creatinine levels and reducing lymph node size. To date, there has been no report in the literature of symptomatic recurrence of hepatic sarcoidosis following orthotopic liver transplantation.

Original languageEnglish (US)
Pages (from-to)1611-1614
Number of pages4
JournalLiver Transplantation
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

Fingerprint Dive into the research topics of 'Recurrent hepatic sarcoidosis post-liver transplantation manifesting with severe hypercalcemia: A case report and review of the literature'. Together they form a unique fingerprint.

  • Cite this

    Cengiz, C., Rodriguez-Davalos, M., de Boccardo, G., Fiel, M. I., Rodriguez-Laiz, G., Kovacevic, M., Emre, S., & Schiano, T. (2005). Recurrent hepatic sarcoidosis post-liver transplantation manifesting with severe hypercalcemia: A case report and review of the literature. Liver Transplantation, 11(12), 1611-1614. https://doi.org/10.1002/lt.20626