Abstract
A 33 year old woman presented with recurrent Cushing’s disease 4 years after complete remission induced by pituitary surgery. On relapse she exhibited the unusual pattern of elevated indices of Cortisol secretion with markedly suppressed serum DHEA-S; urinary 17-ketosteroid excretion was also below the normal range. Biochemical testing was otherwise consistent with ACTH-mediated hyper-cortisolism, and adrenal histopathology showed bilateral hyperplasia with no evidence of tumor. This case illustrates that serum DHEA-S is not an infallible guide to the differential diagnosis of Cushing’s syndrome, and it supports the existence of a pituitary-secreted adrenal androgen stimulating factor that is distinct from ACTH.
Original language | English (US) |
---|---|
Pages (from-to) | 965-969 |
Number of pages | 5 |
Journal | Journal of endocrinological investigation |
Volume | 14 |
Issue number | 11 |
DOIs | |
State | Published - Dec 1991 |
Externally published | Yes |
Keywords
- ACTH
- Recurrent Cushing’s disease
- adrenal androgens
- dehydroepiandrosterone sulfate (DHEAS)
- hypercortisolism
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology