Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation

Lin Jen-Jar Lin; Frederick Miller; Wayne Waltzer; Frederick J. Kaskel; Leonard Arbeit

doi:10.1016/0272-6386(95)90630-4

Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation

Lin Jen-Jar Lin, Frederick Miller, Wayne Waltzer, Frederick J. Kaskel, Leonard Arbeit

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-κ deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.

Original language	English (US)
Pages (from-to)	75-78
Number of pages	4
Journal	American Journal of Kidney Diseases
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/0272-6386(95)90630-4
State	Published - Jan 1995
Externally published	Yes

Keywords

Light and heavy chain deposition disease
immunoglobulin A-κ deposition
posttransplant recurrence
renal transplant
steroid therapy

ASJC Scopus subject areas

Nephrology

Access to Document

10.1016/0272-6386(95)90630-4

Cite this

@article{858de7e407f7471fbea87f6c63cb59f2,

title = "Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation",

abstract = "Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-κ deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.",

keywords = "Light and heavy chain deposition disease, immunoglobulin A-κ deposition, posttransplant recurrence, renal transplant, steroid therapy",

author = "{Jen-Jar Lin}, Lin and Frederick Miller and Wayne Waltzer and Kaskel, {Frederick J.} and Leonard Arbeit",

note = "Funding Information: From the Departments of Pediatrics, and Internal Medicine, State University Brook, Stony Brook, NY. Received May 12, 1994; accepted in revised form IS, 1994. Dr Lin is a recipient of a Fellowship Award and in-Aid Award from the National Kidney Foundation, Address reprint requests to Leonard Arbeit, MD, of Nephrology and Hypertension, Department of Medicine, HSC, T-15, State University of New York Brook, Stony Brook, NY I 1794. 0 I995 by the National Kidney Foundation, 0272-6386/95/2501-0015$3.00/O",

year = "1995",

month = jan,

doi = "10.1016/0272-6386(95)90630-4",

language = "English (US)",

volume = "25",

pages = "75--78",

journal = "American Journal of Kidney Diseases",

issn = "0272-6386",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation

AU - Jen-Jar Lin, Lin

AU - Miller, Frederick

AU - Waltzer, Wayne

AU - Kaskel, Frederick J.

AU - Arbeit, Leonard

N1 - Funding Information: From the Departments of Pediatrics, and Internal Medicine, State University Brook, Stony Brook, NY. Received May 12, 1994; accepted in revised form IS, 1994. Dr Lin is a recipient of a Fellowship Award and in-Aid Award from the National Kidney Foundation, Address reprint requests to Leonard Arbeit, MD, of Nephrology and Hypertension, Department of Medicine, HSC, T-15, State University of New York Brook, Stony Brook, NY I 1794. 0 I995 by the National Kidney Foundation, 0272-6386/95/2501-0015$3.00/O

PY - 1995/1

Y1 - 1995/1

N2 - Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-κ deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.

AB - Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-κ deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.

KW - Light and heavy chain deposition disease

KW - immunoglobulin A-κ deposition

KW - posttransplant recurrence

KW - renal transplant

KW - steroid therapy

UR - http://www.scopus.com/inward/record.url?scp=0028890721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028890721&partnerID=8YFLogxK

U2 - 10.1016/0272-6386(95)90630-4

DO - 10.1016/0272-6386(95)90630-4

M3 - Article

C2 - 7810538

AN - SCOPUS:0028890721

SN - 0272-6386

VL - 25

SP - 75

EP - 78

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

IS - 1

ER -

Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this