Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation

Lin Jen-Jar Lin, Frederick Miller, Wayne Waltzer, Frederick J. Kaskel, Leonard Arbeit

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-κ deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume25
Issue number1
DOIs
StatePublished - Jan 1995

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Keywords

  • Light and heavy chain deposition disease
  • immunoglobulin A-κ deposition
  • posttransplant recurrence
  • renal transplant
  • steroid therapy

ASJC Scopus subject areas

  • Nephrology

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