Rectal diazepam gel in the home management of seizures in children

Christine O'Dell, Shlomo Shinnar, Karen R. Ballaban-Gil, Matthew Hornick, Maryana Sigalova, Harriet Kang, Solomon L. Moshe

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

This study assessed the utility of rectal diazepam gel in the home management of prolonged or repetitive seizures in children. Thirty-eight children being prescribed rectal diazepam gel by their clinician were prospectively recruited. Seizures, rectal diazepam use, emergency department visits, and quality of life data before and after study entry were recorded. The 38 children included 14 (37%) with complex febrile seizures, and 24 with epilepsy (n = 22) or a single seizure (n = 2). There were 23 (61%) children with prolonged seizures and 15 (39%) with repetitive seizures. During the 6-month follow-up period, 12 children experienced 26 seizures which met the criteria for rectal diazepam administration. Rectal diazepam gel was administered to 8 children on 19 occasions. In 16 (84%) of these episodes, seizures stopped and no emergency department visit was required. Parental stress was decreased between baseline and 6 months in both the overall group and in all the subgroups. Home use of rectal diazepam gel is effective in aborting seizure activity, often avoiding an emergency department visit. Its use reduces morbidity and costs associated with hospital visits and provides parents a treatment option for home management of prolonged or repetitive seizures.

Original languageEnglish (US)
Pages (from-to)166-172
Number of pages7
JournalPediatric Neurology
Volume33
Issue number3
DOIs
StatePublished - Sep 2005

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Diazepam
Seizures
Gels
Hospital Emergency Service
Epilepsy
Rectal Administration
Febrile Seizures
Parents
Quality of Life
Morbidity
Costs and Cost Analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Rectal diazepam gel in the home management of seizures in children. / O'Dell, Christine; Shinnar, Shlomo; Ballaban-Gil, Karen R.; Hornick, Matthew; Sigalova, Maryana; Kang, Harriet; Moshe, Solomon L.

In: Pediatric Neurology, Vol. 33, No. 3, 09.2005, p. 166-172.

Research output: Contribution to journalArticle

O'Dell, Christine ; Shinnar, Shlomo ; Ballaban-Gil, Karen R. ; Hornick, Matthew ; Sigalova, Maryana ; Kang, Harriet ; Moshe, Solomon L. / Rectal diazepam gel in the home management of seizures in children. In: Pediatric Neurology. 2005 ; Vol. 33, No. 3. pp. 166-172.
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