Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women

Geoffrey C. Kabat, Mimi Kim, Jean Wactawski-Wende, Dorothy Lane, Lucile L. Adams-Campbell, Mia Gaudet, Marcia L. Stefanick, Mara Vitolins, Rowan T. Chlebowski, Sylvia Wassertheil-Smoller, Thomas E. Rohan

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8 Scopus citations

Abstract

Objective: To assess the association of recreational physical activity and anthropometric factors in relation to risk of ductal carcinoma in situ (DCIS) of the breast. Methods: The association was examined in a cohort of 58,055 postmenopausal women participating in the Women's Health Initiative (WHI) clinical trials, among whom 450 cases of DCIS were ascertained after a median follow-up of 8.0 years. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Results: After adjustment for covariates, the hazard ratio for DCIS among women with ≥20 metabolic equivalent task-hours per week (MET-h/week) of total recreational physical activity compared to women who did not engage in any recreational physical activity (0 MET-h/week) was 0.97 (95% CI 0.70-1.34). Neither body mass index nor waist circumference was associated with risk. In addition, physical activity and anthropometric factors were not associated with risk of either high-grade or low-/moderate-grade DCIS. Conclusions: Recreational physical activity and anthropometric factors showed no association with risk of DCIS in postmenopausal women in the WHI clinical trial.

Original languageEnglish (US)
Pages (from-to)2173-2181
Number of pages9
JournalCancer Causes and Control
Volume21
Issue number12
DOIs
StatePublished - Dec 1 2010

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Keywords

  • Body mass index
  • Breast cancer
  • Ductal carcinoma in situ
  • Physical activity
  • Waist circumference

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kabat, G. C., Kim, M., Wactawski-Wende, J., Lane, D., Adams-Campbell, L. L., Gaudet, M., Stefanick, M. L., Vitolins, M., Chlebowski, R. T., Wassertheil-Smoller, S., & Rohan, T. E. (2010). Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women. Cancer Causes and Control, 21(12), 2173-2181. https://doi.org/10.1007/s10552-010-9637-z