Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women

Geoffrey C. Kabat, Mimi Kim, Jean Wactawski-Wende, Dorothy Lane, Lucile L. Adams-Campbell, Mia Gaudet, Marcia L. Stefanick, Mara Vitolins, Rowan T. Chlebowski, Sylvia Wassertheil-Smoller, Thomas E. Rohan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To assess the association of recreational physical activity and anthropometric factors in relation to risk of ductal carcinoma in situ (DCIS) of the breast. Methods: The association was examined in a cohort of 58,055 postmenopausal women participating in the Women's Health Initiative (WHI) clinical trials, among whom 450 cases of DCIS were ascertained after a median follow-up of 8.0 years. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Results: After adjustment for covariates, the hazard ratio for DCIS among women with ≥20 metabolic equivalent task-hours per week (MET-h/week) of total recreational physical activity compared to women who did not engage in any recreational physical activity (0 MET-h/week) was 0.97 (95% CI 0.70-1.34). Neither body mass index nor waist circumference was associated with risk. In addition, physical activity and anthropometric factors were not associated with risk of either high-grade or low-/moderate-grade DCIS. Conclusions: Recreational physical activity and anthropometric factors showed no association with risk of DCIS in postmenopausal women in the WHI clinical trial.

Original languageEnglish (US)
Pages (from-to)2173-2181
Number of pages9
JournalCancer Causes and Control
Volume21
Issue number12
DOIs
StatePublished - Dec 2010

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Carcinoma, Intraductal, Noninfiltrating
Breast
Exercise
Metabolic Equivalent
Women's Health
Clinical Trials
Confidence Intervals
Waist Circumference
Proportional Hazards Models
Body Mass Index

Keywords

  • Body mass index
  • Breast cancer
  • Ductal carcinoma in situ
  • Physical activity
  • Waist circumference

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women. / Kabat, Geoffrey C.; Kim, Mimi; Wactawski-Wende, Jean; Lane, Dorothy; Adams-Campbell, Lucile L.; Gaudet, Mia; Stefanick, Marcia L.; Vitolins, Mara; Chlebowski, Rowan T.; Wassertheil-Smoller, Sylvia; Rohan, Thomas E.

In: Cancer Causes and Control, Vol. 21, No. 12, 12.2010, p. 2173-2181.

Research output: Contribution to journalArticle

Kabat, GC, Kim, M, Wactawski-Wende, J, Lane, D, Adams-Campbell, LL, Gaudet, M, Stefanick, ML, Vitolins, M, Chlebowski, RT, Wassertheil-Smoller, S & Rohan, TE 2010, 'Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women', Cancer Causes and Control, vol. 21, no. 12, pp. 2173-2181. https://doi.org/10.1007/s10552-010-9637-z
Kabat, Geoffrey C. ; Kim, Mimi ; Wactawski-Wende, Jean ; Lane, Dorothy ; Adams-Campbell, Lucile L. ; Gaudet, Mia ; Stefanick, Marcia L. ; Vitolins, Mara ; Chlebowski, Rowan T. ; Wassertheil-Smoller, Sylvia ; Rohan, Thomas E. / Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women. In: Cancer Causes and Control. 2010 ; Vol. 21, No. 12. pp. 2173-2181.
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