Recombination events that activate, diversify, and delete immunoglobulin genes

P. Leder, E. E. Max, J. G. Seidman, S. P. Kwan, Matthew D. Scharff, M. Nau, B. Norman

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Immunoglobulin κ light-chain diversity arises, in large part, from an array of germ-line V-region genes that undergo somatic recombination with one of four active J-region segments. The diversity provided by this combinational system is increased by a recombination mechanism that allows variation of crossover points so as to generate additional diversity at a critical region of the light chain. The elaborate mechanism for generating diversity is accompanied not only by considerable waste, in terms of unused V and J regions in a given cell, but also by a range of aberrant recombinants that fail to produce active immunoglobulin genes.

Original languageEnglish (US)
Pages (from-to)859-865
Number of pages7
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume45
Issue number2
StatePublished - 1981
Externally publishedYes

Fingerprint

immunoglobulin light chains
immunoglobulin genes
Immunoglobulin Genes
Genetic Recombination
Immunoglobulins
germ cells
Genes
Immunoglobulin Light Chains
Germ Cells
genes
cells
Light

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Leder, P., Max, E. E., Seidman, J. G., Kwan, S. P., Scharff, M. D., Nau, M., & Norman, B. (1981). Recombination events that activate, diversify, and delete immunoglobulin genes. Cold Spring Harbor Symposia on Quantitative Biology, 45(2), 859-865.

Recombination events that activate, diversify, and delete immunoglobulin genes. / Leder, P.; Max, E. E.; Seidman, J. G.; Kwan, S. P.; Scharff, Matthew D.; Nau, M.; Norman, B.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 45, No. 2, 1981, p. 859-865.

Research output: Contribution to journalArticle

Leder, P, Max, EE, Seidman, JG, Kwan, SP, Scharff, MD, Nau, M & Norman, B 1981, 'Recombination events that activate, diversify, and delete immunoglobulin genes', Cold Spring Harbor Symposia on Quantitative Biology, vol. 45, no. 2, pp. 859-865.
Leder, P. ; Max, E. E. ; Seidman, J. G. ; Kwan, S. P. ; Scharff, Matthew D. ; Nau, M. ; Norman, B. / Recombination events that activate, diversify, and delete immunoglobulin genes. In: Cold Spring Harbor Symposia on Quantitative Biology. 1981 ; Vol. 45, No. 2. pp. 859-865.
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