Recombination events that activate, diversify, and delete immunoglobulin genes

P. Leder, E. E. Max, J. G. Seidman, S. P. Kwan, M. Scharff, M. Nau, B. Norman

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17 Scopus citations

Abstract

Immunoglobulin κ light-chain diversity arises, in large part, from an array of germ-line V-region genes that undergo somatic recombination with one of four active J-region segments. The diversity provided by this combinational system is increased by a recombination mechanism that allows variation of crossover points so as to generate additional diversity at a critical region of the light chain. The elaborate mechanism for generating diversity is accompanied not only by considerable waste, in terms of unused V and J regions in a given cell, but also by a range of aberrant recombinants that fail to produce active immunoglobulin genes.

Original languageEnglish (US)
Pages (from-to)859-865
Number of pages7
JournalCold Spring Harbor symposia on quantitative biology
Volume45
Issue number2
Publication statusPublished - Dec 1 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Leder, P., Max, E. E., Seidman, J. G., Kwan, S. P., Scharff, M., Nau, M., & Norman, B. (1981). Recombination events that activate, diversify, and delete immunoglobulin genes. Cold Spring Harbor symposia on quantitative biology, 45(2), 859-865.