Recombination events that activate, diversify, and delete immunoglobulin genes

P. Leder, E. E. Max, J. G. Seidman, S. P. Kwan, M. Scharff, M. Nau, B. Norman

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Immunoglobulin κ light-chain diversity arises, in large part, from an array of germ-line V-region genes that undergo somatic recombination with one of four active J-region segments. The diversity provided by this combinational system is increased by a recombination mechanism that allows variation of crossover points so as to generate additional diversity at a critical region of the light chain. The elaborate mechanism for generating diversity is accompanied not only by considerable waste, in terms of unused V and J regions in a given cell, but also by a range of aberrant recombinants that fail to produce active immunoglobulin genes.

Original languageEnglish (US)
Pages (from-to)859-865
Number of pages7
JournalUnknown Journal
Volume45
Issue number2
DOIs
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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