Abstract
Immunoglobulin κ light-chain diversity arises, in large part, from an array of germ-line V-region genes that undergo somatic recombination with one of four active J-region segments. The diversity provided by this combinational system is increased by a recombination mechanism that allows variation of crossover points so as to generate additional diversity at a critical region of the light chain. The elaborate mechanism for generating diversity is accompanied not only by considerable waste, in terms of unused V and J regions in a given cell, but also by a range of aberrant recombinants that fail to produce active immunoglobulin genes.
Original language | English (US) |
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Pages (from-to) | 859-865 |
Number of pages | 7 |
Journal | Unknown Journal |
Volume | 45 |
Issue number | 2 |
DOIs | |
State | Published - 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics