Recognition of Lipids from Pollens by CD1-Restricted T Cells

Fabrizio Spinozzi, Steven A. Porcelli

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Allergic rhinitis and asthma should be considered as organ-specific inflammatory diseases in which the genetic background has determined a local overproduction of Th2-type cytokines and an overexpansion of particular APCs and T cells. Among the latter, a potential pathogenetic role could be assumed for natural killer T cells, expressing both invariant (Vα24/Vβ11) and classic αβ or γδ T-cell receptors. Recent studies support this notion and also suggest that surface pollen substances of nonprotein structure, such as lipid components recognized by CD1, could be viewed as one of the foreign materials against which the immune system of the allergic subject can mount a local inflammatory response.

Original languageEnglish (US)
Pages (from-to)79-92
Number of pages14
JournalImmunology and Allergy Clinics of North America
Volume27
Issue number1
DOIs
StatePublished - Feb 2007

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Natural Killer T-Cells
T-Cell Antigen Receptor
Pollen
Immune System
Asthma
Cytokines
T-Lymphocytes
Lipids
Genetic Background
Allergic Rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Recognition of Lipids from Pollens by CD1-Restricted T Cells. / Spinozzi, Fabrizio; Porcelli, Steven A.

In: Immunology and Allergy Clinics of North America, Vol. 27, No. 1, 02.2007, p. 79-92.

Research output: Contribution to journalArticle

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