Recognition of cluster of differentiation 1 antigens by human CD4-CD8- cytolytic T lymphocyte

Steven A. Porcelli, Michael B. Brenner, Julia L. Greenstein, Steven P. Balk, Cox Terhorst, Paul A. Bleicher

Research output: Contribution to journalArticle

421 Citations (Scopus)

Abstract

HUMAN cluster-of-differentiation 1 (CD1) is a family of cell surface glycoproteins of unknown function expressed on immature thymocytes, epidermal Langerhans cells and a subset of B lymphocytes1-3. Three homologous proteins, CD la, b and c, have been defined serologically4, and the CD1 gene locus on human chromosome 1 contains five potential CD1 genes5. Analysis of the predicted amino-acid sequences of CD1 molecules reveals a low but significant level of homology to major histocompatibility complex (MHC) class I and class II molecules5,6, and, like MHC class I molecules, CD1 molecules are associated non-covalently with (β2-microglobulin7. These structural similarities to known antigen-presenting molecules, together with the expression of CD1 on cells capable of antigen presentation, suggest a role for CD1 molecules in antigen recognition by T cells. Here we demonstrate the specific recognition of CDla by a CD4-CD8- αβ T-cell receptor (TCR) expressing cytolytic T lymphocyte (CTL) line and the specific recognition of CD1c by a CD4-CD8minus;γδTCR CTL line. The interaction of GDI-specific CTLs with CD1+ target cells appeared to involve the CD3-TCR complex, and did not show evidence of MHC restriction. These results suggest that for a subset of T cells, GDI molecules serve a function analogous to that of MHG class I and II molecules.

Original languageEnglish (US)
Pages (from-to)447-450
Number of pages4
JournalNature
Volume341
Issue number6241
StatePublished - 1989
Externally publishedYes

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CD Antigens
T-Cell Antigen Receptor
Major Histocompatibility Complex
Guanine Nucleotide Dissociation Inhibitors
T-Lymphocytes
Antigens
Langerhans Cells
Chromosomes, Human, Pair 1
Membrane Glycoproteins
Protein Sequence Analysis
Antigen Presentation
Human Chromosomes
T-Lymphocyte Subsets
Thymocytes
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Porcelli, S. A., Brenner, M. B., Greenstein, J. L., Balk, S. P., Terhorst, C., & Bleicher, P. A. (1989). Recognition of cluster of differentiation 1 antigens by human CD4-CD8- cytolytic T lymphocyte. Nature, 341(6241), 447-450.

Recognition of cluster of differentiation 1 antigens by human CD4-CD8- cytolytic T lymphocyte. / Porcelli, Steven A.; Brenner, Michael B.; Greenstein, Julia L.; Balk, Steven P.; Terhorst, Cox; Bleicher, Paul A.

In: Nature, Vol. 341, No. 6241, 1989, p. 447-450.

Research output: Contribution to journalArticle

Porcelli, SA, Brenner, MB, Greenstein, JL, Balk, SP, Terhorst, C & Bleicher, PA 1989, 'Recognition of cluster of differentiation 1 antigens by human CD4-CD8- cytolytic T lymphocyte', Nature, vol. 341, no. 6241, pp. 447-450.
Porcelli SA, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA. Recognition of cluster of differentiation 1 antigens by human CD4-CD8- cytolytic T lymphocyte. Nature. 1989;341(6241):447-450.
Porcelli, Steven A. ; Brenner, Michael B. ; Greenstein, Julia L. ; Balk, Steven P. ; Terhorst, Cox ; Bleicher, Paul A. / Recognition of cluster of differentiation 1 antigens by human CD4-CD8- cytolytic T lymphocyte. In: Nature. 1989 ; Vol. 341, No. 6241. pp. 447-450.
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