Reciprocal role of vasculogenic factors and progenitor cells in atherogenesis

T. Muraya, O. M. Tepper, T. Asahara

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

While neovascularization plays an integral role in atherosclerosis, stimulation of angiogenesis does not appear to promote atherogenesis. This observation is important in view of recent advancements in angiogenic gene and cell therapy aimed at promoting new blood vessel growth in humans with vascular disease. Endothelial progenitor cells (EPCs) may actually prevent rather than provoke intimal thickening and vascular remodeling by promoting re-endothelialization in response to vascular trauma, as occurs with percutaneous transluminal vascular intervention for treating atherosclerotic vessels. Further support for the hypothesis that EPCs continuously repair vascular injury and contribute to the rejuvenation of vessels has been derived from animal studies demonstrating that serial injection of bone marrow-derived EPCs prevent atherogenesis, but that the quantity and quality of these cells deteriorate with aging. This chapter provides a summary of the influence of angiogenesis on atheromatous disease. Furthermore, the increasingly important relationship between atherosclerosis and newly emerging techniques in therapeutic angiogenesis (i.e., gene therapy and cell therapy with EPCs) is discussed.

Original languageEnglish (US)
Title of host publicationAtherosclerosis
Subtitle of host publicationDiet and Drugs
EditorsArnold von Eckardstein
Pages777-783
Number of pages7
DOIs
Publication statusPublished - Dec 1 2005
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume170
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

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Keywords

  • Atherosclerosis
  • Endothelial progenitor cells
  • Neovascularization
  • Vascular injury

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Muraya, T., Tepper, O. M., & Asahara, T. (2005). Reciprocal role of vasculogenic factors and progenitor cells in atherogenesis. In A. V. Eckardstein (Ed.), Atherosclerosis: Diet and Drugs (pp. 777-783). (Handbook of Experimental Pharmacology; Vol. 170). https://doi.org/10.1007/3-540-27661-0-29