Reciprocal influence of connexins and apical junction proteins on their expressions and functions

Mickaël Derangeon, David C. Spray, Nicolas Bourmeyster, Denis Sarrouilhe, Jean Claude Hervé

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Membranes of adjacent cells form intercellular junctional complexes to mechanically anchor neighbour cells (anchoring junctions), to seal the paracellular space and to prevent diffusion of integral proteins within the plasma membrane (tight junctions) and to allow cell-to-cell diffusion of small ions and molecules (gap junctions). These different types of specialised plasma membrane microdomains, sharing common adaptor molecules, particularly zonula occludens proteins, frequently present intermingled relationships where the different proteins co-assemble into macromolecular complexes and their expressions are co-ordinately regulated. Proteins forming gap junction channels (connexins, particularly) and proteins fulfilling cell attachment or forming tight junction strands mutually influence expression and functions of one another.

Original languageEnglish (US)
Pages (from-to)768-778
Number of pages11
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1788
Issue number4
DOIs
StatePublished - Apr 2009

Fingerprint

Connexins
Tight Junctions
Cell Membrane
Zonula Occludens Proteins
Cell membranes
Membrane Microdomains
Macromolecular Substances
Proteins
Intercellular Junctions
Gap Junctions
Molecules
Anchors
Ions
Seals
Membranes

Keywords

  • Adherens junction
  • Apical junction
  • Connexin
  • Gap junction
  • Tight junction
  • ZO-1

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biophysics

Cite this

Reciprocal influence of connexins and apical junction proteins on their expressions and functions. / Derangeon, Mickaël; Spray, David C.; Bourmeyster, Nicolas; Sarrouilhe, Denis; Hervé, Jean Claude.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1788, No. 4, 04.2009, p. 768-778.

Research output: Contribution to journalArticle

Derangeon, Mickaël ; Spray, David C. ; Bourmeyster, Nicolas ; Sarrouilhe, Denis ; Hervé, Jean Claude. / Reciprocal influence of connexins and apical junction proteins on their expressions and functions. In: Biochimica et Biophysica Acta - Biomembranes. 2009 ; Vol. 1788, No. 4. pp. 768-778.
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