Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34

Sayan Nandi, Mario Cioce, Yee Guide Yeung, Edward Nieves, Lydia Tesfa, Haishan Lin, Amy W. Hsu, Robert Halenbeck, Hui Yong Cheng, Solen Gokhan, Mark F. Mehler, E. Richard Stanley

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Background: IL-34 and the known IL-34 receptor, CSF-1R, are differentially expressed in mouse brain; thus, IL-34 may signal via an additional receptor(s). Results: IL-34 binds to PTP-ζ on U251 human glioblastoma cells to stimulate intracellular signaling and responses. Conclusion: PTP-ζ is an IL-34 receptor. Significance: CSF-1R-independent actions of IL-34 via PTP-ζ should be considered in evaluating IL-34 roles in development and disease.

Original languageEnglish (US)
Pages (from-to)21972-21986
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
StatePublished - Jul 26 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Nandi, S., Cioce, M., Yeung, Y. G., Nieves, E., Tesfa, L., Lin, H., Hsu, A. W., Halenbeck, R., Cheng, H. Y., Gokhan, S., Mehler, M. F., & Stanley, E. R. (2013). Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34. Journal of Biological Chemistry, 288(30), 21972-21986. https://doi.org/10.1074/jbc.M112.442731