Abstract
Background: IL-34 and the known IL-34 receptor, CSF-1R, are differentially expressed in mouse brain; thus, IL-34 may signal via an additional receptor(s). Results: IL-34 binds to PTP-ζ on U251 human glioblastoma cells to stimulate intracellular signaling and responses. Conclusion: PTP-ζ is an IL-34 receptor. Significance: CSF-1R-independent actions of IL-34 via PTP-ζ should be considered in evaluating IL-34 roles in development and disease.
Original language | English (US) |
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Pages (from-to) | 21972-21986 |
Number of pages | 15 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 30 |
DOIs | |
State | Published - Jul 26 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology