TY - JOUR
T1 - Receptor trafficking and the regulation of synaptic plasticity by SUMO
AU - Luo, Jia
AU - Ashikaga, Emi
AU - Rubin, Philip P.
AU - Heimann, Michaela J.
AU - Hildick, Keri L.
AU - Bishop, Paul
AU - Girach, Fatima
AU - Josa-Prado, Fernando
AU - Tang, Leo T.H.
AU - Carmichael, Ruth E.
AU - Henley, Jeremy M.
AU - Wilkinson, Kevin A.
N1 - Funding Information:
Acknowledgments We thank Prof. Ron Hay for the kind gift of SUMO-1 and SUMO-2/3 antibodies. We are grateful to the ERC, the MRC, the Wellcome Trust, the BBSRC and Marie Curie for funding.
PY - 2013/12
Y1 - 2013/12
N2 - Timely and efficient information transfer at synapses is fundamental to brain function. Synapses are highly dynamic structures that exhibit long-lasting activity-dependent alterations to their structure and transmission efficiency, a phenomenon termed synaptic plasticity. These changes, which occur through alterations in presynaptic release or in the trafficking of postsynaptic receptor proteins, underpin the formation and stabilisation of neural circuits during brain development, and encode, process and store information essential for learning, memory and cognition. In recent years, it has emerged that the ubiquitin-like posttranslational modification SUMOylation is an important mediator of several aspects of neuronal and synaptic function. Through orchestrating synapse formation, presynaptic release and the trafficking of postsynaptic receptor proteins during forms of synaptic plasticity such as long-term potentiation, long-term depression and homeostatic scaling, SUMOylation is being increasingly appreciated to play a central role in neurotransmission. In this review, we outline key discoveries in this relatively new field, provide an update on recent progress regarding the targets and consequences of protein SUMOylation in synaptic function and plasticity, and highlight key outstanding questions regarding the roles of protein SUMOylation in the brain.
AB - Timely and efficient information transfer at synapses is fundamental to brain function. Synapses are highly dynamic structures that exhibit long-lasting activity-dependent alterations to their structure and transmission efficiency, a phenomenon termed synaptic plasticity. These changes, which occur through alterations in presynaptic release or in the trafficking of postsynaptic receptor proteins, underpin the formation and stabilisation of neural circuits during brain development, and encode, process and store information essential for learning, memory and cognition. In recent years, it has emerged that the ubiquitin-like posttranslational modification SUMOylation is an important mediator of several aspects of neuronal and synaptic function. Through orchestrating synapse formation, presynaptic release and the trafficking of postsynaptic receptor proteins during forms of synaptic plasticity such as long-term potentiation, long-term depression and homeostatic scaling, SUMOylation is being increasingly appreciated to play a central role in neurotransmission. In this review, we outline key discoveries in this relatively new field, provide an update on recent progress regarding the targets and consequences of protein SUMOylation in synaptic function and plasticity, and highlight key outstanding questions regarding the roles of protein SUMOylation in the brain.
KW - Neuronal function
KW - Receptor trafficking
KW - SUMOylation
KW - Synaptic plasticity
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U2 - 10.1007/s12017-013-8253-y
DO - 10.1007/s12017-013-8253-y
M3 - Review article
C2 - 23934328
AN - SCOPUS:84888201040
SN - 1535-1084
VL - 15
SP - 692
EP - 706
JO - NeuroMolecular Medicine
JF - NeuroMolecular Medicine
IS - 4
ER -