TY - JOUR
T1 - Receptor protein-tyrosine phosphatase γ is a candidate tumor suppressor gene at human chromosome region 3p21
AU - LaForgia, S.
AU - Morse, B.
AU - Levy, J.
AU - Barnea, G.
AU - Cannizzaro, L. A.
AU - Li, F.
AU - Nowell, P. C.
AU - Boghosian-Sell, L.
AU - Glick, J.
AU - Weston, A.
AU - Harris, C. C.
AU - Drabkin, H.
AU - Patterson, D.
AU - Croce, C. M.
AU - Schlessinger, J.
AU - Huebner, K.
PY - 1991
Y1 - 1991
N2 - PTPG, the gene for protein-tyrosine phosphatase γ (PTPγ), maps to a region of human chromosome 3, 3p21, that is frequently deleted in renal cell carcinoma and lung carcinoma. One of the functions of protein-tyrosine phosphatases is to reverse the effect of protein-tyrosine kinases, many of which are oncogenes, suggesting that some protein-tyrosine phosphatase genes may act as tumor suppressor genes. A hallmark of tumor suppressor genes is that they are deleted in tumors in which their inactivation contributes to the malignant phenotype. In this study, one PTPγ allele was lost in 3 of 5 renal carcinoma cell lines and 5 of 10 lung carcinoma tumor samples tested. Importantly, one PTPγ allele was lost in three lung tumors that had not lost flanking loci. PTPγ mRNA was expressed in kidney cell lines and lung cell lines but not expressed in several hematopoietic cell lines tested. Thus, the PTPγ gene has characteristics that suggest it as a candidate tumor suppressor gene at 3p21.
AB - PTPG, the gene for protein-tyrosine phosphatase γ (PTPγ), maps to a region of human chromosome 3, 3p21, that is frequently deleted in renal cell carcinoma and lung carcinoma. One of the functions of protein-tyrosine phosphatases is to reverse the effect of protein-tyrosine kinases, many of which are oncogenes, suggesting that some protein-tyrosine phosphatase genes may act as tumor suppressor genes. A hallmark of tumor suppressor genes is that they are deleted in tumors in which their inactivation contributes to the malignant phenotype. In this study, one PTPγ allele was lost in 3 of 5 renal carcinoma cell lines and 5 of 10 lung carcinoma tumor samples tested. Importantly, one PTPγ allele was lost in three lung tumors that had not lost flanking loci. PTPγ mRNA was expressed in kidney cell lines and lung cell lines but not expressed in several hematopoietic cell lines tested. Thus, the PTPγ gene has characteristics that suggest it as a candidate tumor suppressor gene at 3p21.
KW - chromosome deletions
KW - dephosphorylation
KW - loss of heterozygosity
KW - somatic cell hybrids
KW - translocations
KW - tyrosine phosphorylation
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U2 - 10.1073/pnas.88.11.5036
DO - 10.1073/pnas.88.11.5036
M3 - Article
C2 - 1711217
AN - SCOPUS:0025757145
SN - 0027-8424
VL - 88
SP - 5036
EP - 5040
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 11
ER -