Discovered serendipitously in the course of studies on the mechanism of glucagon stimulation of hepatic cyclic AMP formation, G-proteins have emerged as an expanding family of signal transducers, coupling diverse receptors and effectors. Quantitative and/or qualitative changes in G-proteins may profoundly affect hormone action, and can lead to clinically apparent endocrine dysfunction.
|Original language||English (US)|
|Number of pages||5|
|Journal||Trends in Endocrinology and Metabolism|
|State||Published - 1989|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism