Receptor-effector coupling by G-proteins implications for endocrinology

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Discovered serendipitously in the course of studies on the mechanism of glucagon stimulation of hepatic cyclic AMP formation, G-proteins have emerged as an expanding family of signal transducers, coupling diverse receptors and effectors. Quantitative and/or qualitative changes in G-proteins may profoundly affect hormone action, and can lead to clinically apparent endocrine dysfunction.

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalTrends in Endocrinology and Metabolism
Volume1
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Endocrinology
GTP-Binding Proteins
Glucagon
Transducers
Cyclic AMP
Hormones
Liver

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Receptor-effector coupling by G-proteins implications for endocrinology. / Spiegel, Allen M.

In: Trends in Endocrinology and Metabolism, Vol. 1, No. 2, 1989, p. 72-76.

Research output: Contribution to journalArticle

@article{a49761eaa52842a299dbfda42f4904e8,
title = "Receptor-effector coupling by G-proteins implications for endocrinology",
abstract = "Discovered serendipitously in the course of studies on the mechanism of glucagon stimulation of hepatic cyclic AMP formation, G-proteins have emerged as an expanding family of signal transducers, coupling diverse receptors and effectors. Quantitative and/or qualitative changes in G-proteins may profoundly affect hormone action, and can lead to clinically apparent endocrine dysfunction.",
author = "Spiegel, {Allen M.}",
year = "1989",
doi = "10.1016/1043-2760(89)90006-4",
language = "English (US)",
volume = "1",
pages = "72--76",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Receptor-effector coupling by G-proteins implications for endocrinology

AU - Spiegel, Allen M.

PY - 1989

Y1 - 1989

N2 - Discovered serendipitously in the course of studies on the mechanism of glucagon stimulation of hepatic cyclic AMP formation, G-proteins have emerged as an expanding family of signal transducers, coupling diverse receptors and effectors. Quantitative and/or qualitative changes in G-proteins may profoundly affect hormone action, and can lead to clinically apparent endocrine dysfunction.

AB - Discovered serendipitously in the course of studies on the mechanism of glucagon stimulation of hepatic cyclic AMP formation, G-proteins have emerged as an expanding family of signal transducers, coupling diverse receptors and effectors. Quantitative and/or qualitative changes in G-proteins may profoundly affect hormone action, and can lead to clinically apparent endocrine dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=0024377126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024377126&partnerID=8YFLogxK

U2 - 10.1016/1043-2760(89)90006-4

DO - 10.1016/1043-2760(89)90006-4

M3 - Article

AN - SCOPUS:0024377126

VL - 1

SP - 72

EP - 76

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 2

ER -