Receptor-effector coupling by G-proteins implications for endocrinology

Allen M. Spiegel

doi:10.1016/1043-2760(89)90006-4

Receptor-effector coupling by G-proteins implications for endocrinology

Allen M. Spiegel

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Discovered serendipitously in the course of studies on the mechanism of glucagon stimulation of hepatic cyclic AMP formation, G-proteins have emerged as an expanding family of signal transducers, coupling diverse receptors and effectors. Quantitative and/or qualitative changes in G-proteins may profoundly affect hormone action, and can lead to clinically apparent endocrine dysfunction.

Original language	English (US)
Pages (from-to)	72-76
Number of pages	5
Journal	Trends in Endocrinology and Metabolism
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/1043-2760(89)90006-4
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/1043-2760(89)90006-4

Cite this

@article{a49761eaa52842a299dbfda42f4904e8,

title = "Receptor-effector coupling by G-proteins implications for endocrinology",

abstract = "Discovered serendipitously in the course of studies on the mechanism of glucagon stimulation of hepatic cyclic AMP formation, G-proteins have emerged as an expanding family of signal transducers, coupling diverse receptors and effectors. Quantitative and/or qualitative changes in G-proteins may profoundly affect hormone action, and can lead to clinically apparent endocrine dysfunction.",

author = "Spiegel, {Allen M.}",

year = "1989",

doi = "10.1016/1043-2760(89)90006-4",

language = "English (US)",

volume = "1",

pages = "72--76",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Receptor-effector coupling by G-proteins implications for endocrinology

AU - Spiegel, Allen M.

PY - 1989

Y1 - 1989

N2 - Discovered serendipitously in the course of studies on the mechanism of glucagon stimulation of hepatic cyclic AMP formation, G-proteins have emerged as an expanding family of signal transducers, coupling diverse receptors and effectors. Quantitative and/or qualitative changes in G-proteins may profoundly affect hormone action, and can lead to clinically apparent endocrine dysfunction.

AB - Discovered serendipitously in the course of studies on the mechanism of glucagon stimulation of hepatic cyclic AMP formation, G-proteins have emerged as an expanding family of signal transducers, coupling diverse receptors and effectors. Quantitative and/or qualitative changes in G-proteins may profoundly affect hormone action, and can lead to clinically apparent endocrine dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=0024377126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024377126&partnerID=8YFLogxK

U2 - 10.1016/1043-2760(89)90006-4

DO - 10.1016/1043-2760(89)90006-4

M3 - Review article

AN - SCOPUS:0024377126

SN - 1043-2760

VL - 1

SP - 72

EP - 76

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 2

ER -

Receptor-effector coupling by G-proteins implications for endocrinology

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this