TY - JOUR
T1 - Recent developments in mycobacterial research
AU - Steyn, Andries J.C.
AU - Chan, John
AU - Mehra, Vijay
PY - 1999
Y1 - 1999
N2 - Tuberculosis remains a major health problem in the world, which is compounded further by the alarmingly high rate of M. tuberculosis infections in AIDS patients. Thus, there is an urgent need to advance our understanding of the mycobacterium to develop new drugs. The extraordinary recent developments in mycobacterial genetic research, particularly in genomics will greatly facilitate this goal. The knowledge of the entire genome sequence of M. tuberculosis will help in designing new chemotherapeutic and immunotherapeutic interventions. This review highlights recent developments in genomics, mycobacterial genetics, novel vaccine strategies, and our understanding of tuberculous dormancy.
AB - Tuberculosis remains a major health problem in the world, which is compounded further by the alarmingly high rate of M. tuberculosis infections in AIDS patients. Thus, there is an urgent need to advance our understanding of the mycobacterium to develop new drugs. The extraordinary recent developments in mycobacterial genetic research, particularly in genomics will greatly facilitate this goal. The knowledge of the entire genome sequence of M. tuberculosis will help in designing new chemotherapeutic and immunotherapeutic interventions. This review highlights recent developments in genomics, mycobacterial genetics, novel vaccine strategies, and our understanding of tuberculous dormancy.
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U2 - 10.1097/00001432-199910000-00002
DO - 10.1097/00001432-199910000-00002
M3 - Review article
C2 - 17035806
AN - SCOPUS:0032805930
SN - 0951-7375
VL - 12
SP - 415
EP - 424
JO - Current Opinion in Infectious Diseases
JF - Current Opinion in Infectious Diseases
IS - 5
ER -
