Recent developments in mycobacterial research

Andries J.C. Steyn, John Chan, Vijay Mehra

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Tuberculosis remains a major health problem in the world, which is compounded further by the alarmingly high rate of M. tuberculosis infections in AIDS patients. Thus, there is an urgent need to advance our understanding of the mycobacterium to develop new drugs. The extraordinary recent developments in mycobacterial genetic research, particularly in genomics will greatly facilitate this goal. The knowledge of the entire genome sequence of M. tuberculosis will help in designing new chemotherapeutic and immunotherapeutic interventions. This review highlights recent developments in genomics, mycobacterial genetics, novel vaccine strategies, and our understanding of tuberculous dormancy.

Original languageEnglish (US)
Pages (from-to)415-424
Number of pages10
JournalCurrent Opinion in Infectious Diseases
Volume12
Issue number5
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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