Recent aspects of mammalian fertilization research

Paul M. Wassarman, Luca Jovine, Huayu Qi, Zev Williams, Costel Darie, Eveline S. Litscher

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Mammalian fertilization has been the subject of intensified research in recent times. Application of recombinant DNA, transgenic and gene targeting technology, in particular, to issues in mammalian fertilization has revolutionized the field. Here, we present some of the latest results coming from application of these and other technologies to four aspects of mammalian fertilization: 1. formation of the egg zona pellucida (ZP) during oocyte growth; 2. species-specific binding of sperm to the egg zona pellucida; 3. induction of the sperm acrosome reaction (AR) by the egg zona pellucida; 4. binding of sperm to and fusion with egg plasma membrane. In virtually every instance, new information and new insights have come from relatively recent investigations.

Original languageEnglish (US)
Pages (from-to)95-103
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume234
Issue number1-2
DOIs
StatePublished - Apr 29 2005
Externally publishedYes

Fingerprint

Fertilization
Zona Pellucida
Ovum
Spermatozoa
Recombinant DNA
Cell membranes
Research
Fusion reactions
Genes
Technology
Acrosome Reaction
Gene Targeting
Oocytes
Cell Membrane
Growth

Keywords

  • Acrosome
  • Egg
  • Fertilization
  • Sperm
  • Zona pellucida

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Wassarman, P. M., Jovine, L., Qi, H., Williams, Z., Darie, C., & Litscher, E. S. (2005). Recent aspects of mammalian fertilization research. Molecular and Cellular Endocrinology, 234(1-2), 95-103. https://doi.org/10.1016/j.mce.2004.08.017

Recent aspects of mammalian fertilization research. / Wassarman, Paul M.; Jovine, Luca; Qi, Huayu; Williams, Zev; Darie, Costel; Litscher, Eveline S.

In: Molecular and Cellular Endocrinology, Vol. 234, No. 1-2, 29.04.2005, p. 95-103.

Research output: Contribution to journalArticle

Wassarman, PM, Jovine, L, Qi, H, Williams, Z, Darie, C & Litscher, ES 2005, 'Recent aspects of mammalian fertilization research', Molecular and Cellular Endocrinology, vol. 234, no. 1-2, pp. 95-103. https://doi.org/10.1016/j.mce.2004.08.017
Wassarman PM, Jovine L, Qi H, Williams Z, Darie C, Litscher ES. Recent aspects of mammalian fertilization research. Molecular and Cellular Endocrinology. 2005 Apr 29;234(1-2):95-103. https://doi.org/10.1016/j.mce.2004.08.017
Wassarman, Paul M. ; Jovine, Luca ; Qi, Huayu ; Williams, Zev ; Darie, Costel ; Litscher, Eveline S. / Recent aspects of mammalian fertilization research. In: Molecular and Cellular Endocrinology. 2005 ; Vol. 234, No. 1-2. pp. 95-103.
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