Recent advances in transcatheter aortic valve replacement for high-risk patients

Antonio Mangieri, Damiano Regazzoli, Neil Ruparelia, Antonio Colombo, Azeem Latib

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Aortic stenosis is the most common valvular heart disease of old age. Patients with severe aortic stenosis who develop symptoms have a very poor prognosis without valve intervention. Surgical aortic valve replacement has historically been the only treatment option for these patients. However a significant minority are considered inoperable or at high surgical risk and therefore are refused or decline surgery. In recent years, transcatheter aortic valve replacement has emerged as an alternative treatment option in these high-risk patients. The aim of this review is to summarize the current role of transcatheter aortic valve replacement in contemporary clinical practice including recent advances in technological and procedural aspects and then discuss future directions.

Original languageEnglish (US)
Pages (from-to)1237-1249
Number of pages13
JournalExpert Review of Cardiovascular Therapy
Issue number11
StatePublished - Nov 2 2015
Externally publishedYes


  • TAVR
  • Transcatheter aortic valve replacement
  • aortic stenosis

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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