Recent advances in “sickle and niche” research - Tribute to Dr. Paul S Frenette -

Lidiane S. Torres, Noboru Asada, Mitchell J. Weiss, Andreas Trumpp, Toshio Suda, David T. Scadden, Keisuke Ito

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

In this retrospective, we review the two research topics that formed the basis of the outstanding career of Dr. Paul S. Frenette. In the first part, we focus on sickle cell disease (SCD). The defining feature of SCD is polymerization of the deoxygenated mutant hemoglobin, which leads to a vicious cycle of hemolysis and vaso-occlusion. We survey important discoveries in SCD pathophysiology that have led to recent advances in treatment of SCD. The second part focuses on the hematopoietic stem cell (HSC) niche, the complex microenvironment within the bone marrow that controls HSC function and homeostasis. We detail the cells that constitute this niche, and the factors that these cells use to exert control over hematopoiesis. Here, we trace the scientific paths of Dr. Frenette, highlight key aspects of his research, and identify his most important scientific contributions in both fields.

Original languageEnglish (US)
Pages (from-to)1509-1535
Number of pages27
JournalStem Cell Reports
Volume17
Issue number7
DOIs
StatePublished - Jul 12 2022

Keywords

  • hematopoietic stem cell
  • niche
  • sickle cell disease

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Recent advances in “sickle and niche” research - Tribute to Dr. Paul S Frenette -'. Together they form a unique fingerprint.

Cite this