Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma

Francesco Lo Coco, B. Hilda Ye, Florigio Lista, Paolo Corradini, Kenneth Offit, Daniel M. Knowles, R. S K Chaganti, Riccardo Dalla-Favera

Research output: Contribution to journalArticle

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Abstract

The pathogenesis of non-Hodgkin's lymphoma (NHL) with a large cell component (DLLC, including diffuse large cell, DLCL; diffuse mixed cell, MX- D; and immunoblastic, IMB) is unknown. A novel candidate proto-oncogene, BCL6, that is involved in chromosome band 3q27 aberrations in NHL has been recently identified. We have investigated the incidence and disease- specificity of BCL6 rearrangements in a large panel of lymphoid tumors, including acute and chronic lymphoid leukemias (96 cases), various NHL types (125 cases), and multiple myelomas (23 cases). BCL6 rearrangements were found in 16/45 (35.5%) DLLC, more frequently in DLCL (15/33, 45%) than in MX-D (1/10, 10%), in 2/31 (6.4%) follicular NHL, and in no other tumor types. BCL6 rearrangements represent the first genetic lesion specifically and recurrently associated with DLLC and should prove useful for understanding the pathogenesis as well as for the clinical monitoring of these tumors.

Original languageEnglish (US)
Pages (from-to)1757-1759
Number of pages3
JournalBlood
Volume83
Issue number7
StatePublished - Apr 1 1994
Externally publishedYes

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Gene Rearrangement
Non-Hodgkin's Lymphoma
Tumors
Genes
Chromosomes
Aberrations
Neoplasms
Follicular Lymphoma
Proto-Oncogenes
Cellular Structures
Multiple Myeloma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Monitoring
Incidence

ASJC Scopus subject areas

  • Hematology

Cite this

Lo Coco, F., Ye, B. H., Lista, F., Corradini, P., Offit, K., Knowles, D. M., ... Dalla-Favera, R. (1994). Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood, 83(7), 1757-1759.

Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. / Lo Coco, Francesco; Ye, B. Hilda; Lista, Florigio; Corradini, Paolo; Offit, Kenneth; Knowles, Daniel M.; Chaganti, R. S K; Dalla-Favera, Riccardo.

In: Blood, Vol. 83, No. 7, 01.04.1994, p. 1757-1759.

Research output: Contribution to journalArticle

Lo Coco, F, Ye, BH, Lista, F, Corradini, P, Offit, K, Knowles, DM, Chaganti, RSK & Dalla-Favera, R 1994, 'Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma', Blood, vol. 83, no. 7, pp. 1757-1759.
Lo Coco F, Ye BH, Lista F, Corradini P, Offit K, Knowles DM et al. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood. 1994 Apr 1;83(7):1757-1759.
Lo Coco, Francesco ; Ye, B. Hilda ; Lista, Florigio ; Corradini, Paolo ; Offit, Kenneth ; Knowles, Daniel M. ; Chaganti, R. S K ; Dalla-Favera, Riccardo. / Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. In: Blood. 1994 ; Vol. 83, No. 7. pp. 1757-1759.
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