Reactive arthritis associated with Clostridium difficile pseudomembranous colitis

Chaim Putterman, Alan Rubinow

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Reactive arthritis is associated with several gastrointestinal pathogens, particularly Shigella, Salmonella, Campylobacter, and Yersinia. Another, less well recognized bowel infection leading to reactive arthritis is pseudomembranous colitis, caused by Clostridium difficile. An illustrative case is presented, and the clinical features and characteristics of all reported patients with this association are reviewed. The pathogenesis of the reactive arthritis seems to be related to an immunological response in joints and other tissues against bacterial antigens, which gain access to the systemic circulation through increased intestinal permeability. Therapy with nonspecific antiinflammatory drugs, antiolostridial agents, or a combination of the above is effective. Despite the possibility of persistent articular involvement after gastrointestinal symptoms have subsided, the long-term prognosis seems to be excellent.

Original languageEnglish (US)
Pages (from-to)420-426
Number of pages7
JournalSeminars in Arthritis and Rheumatism
Volume22
Issue number6
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Pseudomembranous Enterocolitis
Reactive Arthritis
Clostridium difficile
Joints
Bacterial Antigens
Yersinia
Shigella
Campylobacter
Salmonella
Permeability
Anti-Inflammatory Agents
Infection
Pharmaceutical Preparations
Therapeutics

Keywords

  • Clostridium difficile
  • enteropathic arthropathy
  • pseudomembranous colitis
  • Reactive arthritis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Rheumatology
  • Orthopedics and Sports Medicine

Cite this

Reactive arthritis associated with Clostridium difficile pseudomembranous colitis. / Putterman, Chaim; Rubinow, Alan.

In: Seminars in Arthritis and Rheumatism, Vol. 22, No. 6, 1993, p. 420-426.

Research output: Contribution to journalArticle

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