Re-Engineering the Liver with Natural Biomaterials

Sanjeev Gupta, Harmeet Malhi, Giridhar R. Gorla

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The extensive regenerative capacity of hepatocytes and the key roles of the liver in metabolic processes have generated interest in the liver as an appropriate target for cell and gene therapy. If cells were considered as natural biomaterials, then liver cell transplantation would fall within the general field of bioengineering. While unmodified hepatocytes engraft in the liver and ectopic sites, biological modifications and optimization of bioengineered systems would facilitate engraftment and survival of transplanted cells, especially in ectopic locations. Acute liver failure, chronic liver disease and metabolic deficiency states are among the conditions that can potentially be treated by cell transplantation. In acute liver failure, cell transplantation into the liver, along with the creation of an extrahepatic reservoir of cells might be required because engraftment and proliferation of transplanted cells in the liver needs time. In other situations, gradual liver repopulation alone might well be effective without additional manipulations.

Original languageEnglish (US)
Pages (from-to)814-824
Number of pages11
JournalYonsei Medical Journal
Volume41
Issue number6
StatePublished - Dec 2000

Fingerprint

Biocompatible Materials
Liver
Cell Transplantation
Acute Liver Failure
Hepatocytes
Bioengineering
Cell- and Tissue-Based Therapy
Genetic Therapy
Liver Transplantation
Liver Diseases
Cell Survival
Chronic Disease
Cell Proliferation

Keywords

  • Hepatocyte
  • Liver
  • Transplantation
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gupta, S., Malhi, H., & Gorla, G. R. (2000). Re-Engineering the Liver with Natural Biomaterials. Yonsei Medical Journal, 41(6), 814-824.

Re-Engineering the Liver with Natural Biomaterials. / Gupta, Sanjeev; Malhi, Harmeet; Gorla, Giridhar R.

In: Yonsei Medical Journal, Vol. 41, No. 6, 12.2000, p. 814-824.

Research output: Contribution to journalArticle

Gupta, S, Malhi, H & Gorla, GR 2000, 'Re-Engineering the Liver with Natural Biomaterials', Yonsei Medical Journal, vol. 41, no. 6, pp. 814-824.
Gupta, Sanjeev ; Malhi, Harmeet ; Gorla, Giridhar R. / Re-Engineering the Liver with Natural Biomaterials. In: Yonsei Medical Journal. 2000 ; Vol. 41, No. 6. pp. 814-824.
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