TY - JOUR
T1 - RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans
AU - Wu, Ying
AU - Li, Huaixing
AU - Loos, Ruth J.F.
AU - Qi, Qibin
AU - Hu, Frank B.
AU - Liu, Yong
AU - Lin, Xu
PY - 2009/7
Y1 - 2009/7
N2 - We previously found that plasma RBP4 levels were strongly associated with metabolic syndrome components. This study aimed to determine whether RBP4 variants are associated with the metabolic syndrome components and plasma RBP4 levels, and to investigate whether the associations between plasma RBP4 and the metabolic syndrome components are causal. Five tagSNPs were tested for their associations with plasma RBP4 levels and metabolic syndrome components in a population-based sample of 3,210 Chinese Hans. A possible causal relationship between plasma RBP4 levels and hypertriglyceridemia was explored by Mendelian randomization. Plasma RBP4 levels were significantly associated with rs10882273 (βz -0.10SD[2 -0.17, -0.03], P = 0.0050), rs3758538 (βz -0.13SD[ -0.24, -0.02], P = 0.0249) in all participants, and with rs17108993 in Shanghai participants (βz -0.19SD[ -0.32, -0.05], P = 0.0061). The single nucleotide polymorphism (SNP) rs3758538 was significantly associated with hypertriglyceridemia (OR 0.62 [0.45-0.85], P = 0.0026) and triglycerides (βz -0.19SD [-0.30, -0.07], P = 0.001) in all participants. In Mendelian randomization analysis, the observed effect size of association between rs3758538 and hypertriglyceridemia was different from the expected effect size (P = 0.0213). This is the first study to show that the RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. However, results of Mendelian randomization do not support the hypothesis thatRBP4 levels are causally related to hypertriglyceridemia risk.
AB - We previously found that plasma RBP4 levels were strongly associated with metabolic syndrome components. This study aimed to determine whether RBP4 variants are associated with the metabolic syndrome components and plasma RBP4 levels, and to investigate whether the associations between plasma RBP4 and the metabolic syndrome components are causal. Five tagSNPs were tested for their associations with plasma RBP4 levels and metabolic syndrome components in a population-based sample of 3,210 Chinese Hans. A possible causal relationship between plasma RBP4 levels and hypertriglyceridemia was explored by Mendelian randomization. Plasma RBP4 levels were significantly associated with rs10882273 (βz -0.10SD[2 -0.17, -0.03], P = 0.0050), rs3758538 (βz -0.13SD[ -0.24, -0.02], P = 0.0249) in all participants, and with rs17108993 in Shanghai participants (βz -0.19SD[ -0.32, -0.05], P = 0.0061). The single nucleotide polymorphism (SNP) rs3758538 was significantly associated with hypertriglyceridemia (OR 0.62 [0.45-0.85], P = 0.0026) and triglycerides (βz -0.19SD [-0.30, -0.07], P = 0.001) in all participants. In Mendelian randomization analysis, the observed effect size of association between rs3758538 and hypertriglyceridemia was different from the expected effect size (P = 0.0213). This is the first study to show that the RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. However, results of Mendelian randomization do not support the hypothesis thatRBP4 levels are causally related to hypertriglyceridemia risk.
KW - Mendelian randomization
KW - SNP
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U2 - 10.1194/jlr.P900014-JLR200
DO - 10.1194/jlr.P900014-JLR200
M3 - Article
C2 - 19287041
AN - SCOPUS:67650552639
SN - 0022-2275
VL - 50
SP - 1479
EP - 1486
JO - Journal of Lipid Research
JF - Journal of Lipid Research
IS - 7
ER -