Rationale for growth hormone therapy in children with chronic kidney disease

Larry A. Greenbaum, Marcela Del Rio, Fatai Bamgbola, Frederick Kaskel

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Growth retardation is a common complication in children with chronic kidney disease. Treatable causes of growth retardation in these patients include renal osteodystrophy, metabolic acidosis, and inadequate nutritional intake. In addition, disturbances in the growth hormone-insulinlike growth factor I axis are a major cause of decreased growth. Administration of recombinant human growth hormone can overcome this problem, allowing catch-up growth and achievement of normal or improved adult height.

Original languageEnglish (US)
Pages (from-to)377-386
Number of pages10
JournalAdvances in Chronic Kidney Disease
Volume11
Issue number4
DOIs
StatePublished - Oct 1 2004

Keywords

  • Chronic kidney disease
  • IGF-I
  • growth failure
  • recombinant human growth hormone

ASJC Scopus subject areas

  • Nephrology

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