Rationale and design of the NO-PARTY trial: Near-zero fluoroscopic exposure during catheter ablation of supraventricular arrhythmias in young patients

Michela Casella, Antonio Dello Russo, Gemma Pelargonio, Maria Grazia Bongiorni, Maurizio Del Greco, Marcello Piacenti, Maria Grazia Andreassi, Pasquale Santangeli, Stefano Bartoletti, Massimo Moltrasio, Gaetano Fassini, Massimiliano Marini, Andrea Di Cori, Luigi Di Biase, Cesare Fiorentini, Paolo Zecchi, Andrea Natale, Eugenio Picano, Claudio Tondo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Introduction Radiofrequency catheter ablation is the mainstay of therapy for supraventricular tachyarrhythmias. Conventional radiofrequency catheter ablation requires the use of fluoroscopy, thus exposing patients to ionising radiation. The feasibility and safety of non-fluoroscopic radiofrequency catheter ablation has been recently reported in a wide range of supraventricular tachyarrhythmias using the EnSite NavX™ mapping system. The NO-PARTY is a multi-centre, randomised controlled trial designed to test the hypothesis that catheter ablation of supraventricular tachyarrhythmias guided by the EnSite NavX™ mapping system results in a clinically significant reduction in exposure to ionising radiation compared with conventional catheter ablation. Methods The study will randomise 210 patients undergoing catheter ablation of supraventricular tachyarrhythmias to either a conventional ablation technique or one guided by the EnSite NavX™ mapping system. The primary end-point is the reduction of the radiation dose to the patient. Secondary end-points include procedural success, reduction of the radiation dose to the operator, and a cost-effectiveness analysis. In a subgroup of patients, we will also evaluate the radiobiological effectiveness of dose reduction by assessing acute chromosomal DNA damage in peripheral blood lymphocytes. Conclusions NO-PARTY will determine whether radiofrequency catheter ablation of supraventricular tachyarrhythmias guided by the EnSite NavX™ mapping system is a suitable and cost-effective approach to achieve a clinically significant reduction in ionising radiation exposure for both patient and operator.

Original languageEnglish (US)
Pages (from-to)539-546
Number of pages8
JournalCardiology in the Young
Volume22
Issue number5
DOIs
StatePublished - Oct 2012
Externally publishedYes

Fingerprint

Catheter Ablation
Cardiac Arrhythmias
Tachycardia
Ionizing Radiation
Ablation Techniques
Radiation
Fluoroscopy
DNA Damage
Cost-Benefit Analysis
Randomized Controlled Trials
Lymphocytes
Safety
Costs and Cost Analysis

Keywords

  • accessory pathway
  • Atrioventricular nodal reentrant tachycardia
  • electroanatomical mapping
  • radiation exposure
  • radiofrequency catheter ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Rationale and design of the NO-PARTY trial : Near-zero fluoroscopic exposure during catheter ablation of supraventricular arrhythmias in young patients. / Casella, Michela; Dello Russo, Antonio; Pelargonio, Gemma; Bongiorni, Maria Grazia; Del Greco, Maurizio; Piacenti, Marcello; Andreassi, Maria Grazia; Santangeli, Pasquale; Bartoletti, Stefano; Moltrasio, Massimo; Fassini, Gaetano; Marini, Massimiliano; Di Cori, Andrea; Di Biase, Luigi; Fiorentini, Cesare; Zecchi, Paolo; Natale, Andrea; Picano, Eugenio; Tondo, Claudio.

In: Cardiology in the Young, Vol. 22, No. 5, 10.2012, p. 539-546.

Research output: Contribution to journalArticle

Casella, M, Dello Russo, A, Pelargonio, G, Bongiorni, MG, Del Greco, M, Piacenti, M, Andreassi, MG, Santangeli, P, Bartoletti, S, Moltrasio, M, Fassini, G, Marini, M, Di Cori, A, Di Biase, L, Fiorentini, C, Zecchi, P, Natale, A, Picano, E & Tondo, C 2012, 'Rationale and design of the NO-PARTY trial: Near-zero fluoroscopic exposure during catheter ablation of supraventricular arrhythmias in young patients', Cardiology in the Young, vol. 22, no. 5, pp. 539-546. https://doi.org/10.1017/S1047951112000042
Casella, Michela ; Dello Russo, Antonio ; Pelargonio, Gemma ; Bongiorni, Maria Grazia ; Del Greco, Maurizio ; Piacenti, Marcello ; Andreassi, Maria Grazia ; Santangeli, Pasquale ; Bartoletti, Stefano ; Moltrasio, Massimo ; Fassini, Gaetano ; Marini, Massimiliano ; Di Cori, Andrea ; Di Biase, Luigi ; Fiorentini, Cesare ; Zecchi, Paolo ; Natale, Andrea ; Picano, Eugenio ; Tondo, Claudio. / Rationale and design of the NO-PARTY trial : Near-zero fluoroscopic exposure during catheter ablation of supraventricular arrhythmias in young patients. In: Cardiology in the Young. 2012 ; Vol. 22, No. 5. pp. 539-546.
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abstract = "Introduction Radiofrequency catheter ablation is the mainstay of therapy for supraventricular tachyarrhythmias. Conventional radiofrequency catheter ablation requires the use of fluoroscopy, thus exposing patients to ionising radiation. The feasibility and safety of non-fluoroscopic radiofrequency catheter ablation has been recently reported in a wide range of supraventricular tachyarrhythmias using the EnSite NavX™ mapping system. The NO-PARTY is a multi-centre, randomised controlled trial designed to test the hypothesis that catheter ablation of supraventricular tachyarrhythmias guided by the EnSite NavX™ mapping system results in a clinically significant reduction in exposure to ionising radiation compared with conventional catheter ablation. Methods The study will randomise 210 patients undergoing catheter ablation of supraventricular tachyarrhythmias to either a conventional ablation technique or one guided by the EnSite NavX™ mapping system. The primary end-point is the reduction of the radiation dose to the patient. Secondary end-points include procedural success, reduction of the radiation dose to the operator, and a cost-effectiveness analysis. In a subgroup of patients, we will also evaluate the radiobiological effectiveness of dose reduction by assessing acute chromosomal DNA damage in peripheral blood lymphocytes. Conclusions NO-PARTY will determine whether radiofrequency catheter ablation of supraventricular tachyarrhythmias guided by the EnSite NavX™ mapping system is a suitable and cost-effective approach to achieve a clinically significant reduction in ionising radiation exposure for both patient and operator.",
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T1 - Rationale and design of the NO-PARTY trial

T2 - Near-zero fluoroscopic exposure during catheter ablation of supraventricular arrhythmias in young patients

AU - Casella, Michela

AU - Dello Russo, Antonio

AU - Pelargonio, Gemma

AU - Bongiorni, Maria Grazia

AU - Del Greco, Maurizio

AU - Piacenti, Marcello

AU - Andreassi, Maria Grazia

AU - Santangeli, Pasquale

AU - Bartoletti, Stefano

AU - Moltrasio, Massimo

AU - Fassini, Gaetano

AU - Marini, Massimiliano

AU - Di Cori, Andrea

AU - Di Biase, Luigi

AU - Fiorentini, Cesare

AU - Zecchi, Paolo

AU - Natale, Andrea

AU - Picano, Eugenio

AU - Tondo, Claudio

PY - 2012/10

Y1 - 2012/10

N2 - Introduction Radiofrequency catheter ablation is the mainstay of therapy for supraventricular tachyarrhythmias. Conventional radiofrequency catheter ablation requires the use of fluoroscopy, thus exposing patients to ionising radiation. The feasibility and safety of non-fluoroscopic radiofrequency catheter ablation has been recently reported in a wide range of supraventricular tachyarrhythmias using the EnSite NavX™ mapping system. The NO-PARTY is a multi-centre, randomised controlled trial designed to test the hypothesis that catheter ablation of supraventricular tachyarrhythmias guided by the EnSite NavX™ mapping system results in a clinically significant reduction in exposure to ionising radiation compared with conventional catheter ablation. Methods The study will randomise 210 patients undergoing catheter ablation of supraventricular tachyarrhythmias to either a conventional ablation technique or one guided by the EnSite NavX™ mapping system. The primary end-point is the reduction of the radiation dose to the patient. Secondary end-points include procedural success, reduction of the radiation dose to the operator, and a cost-effectiveness analysis. In a subgroup of patients, we will also evaluate the radiobiological effectiveness of dose reduction by assessing acute chromosomal DNA damage in peripheral blood lymphocytes. Conclusions NO-PARTY will determine whether radiofrequency catheter ablation of supraventricular tachyarrhythmias guided by the EnSite NavX™ mapping system is a suitable and cost-effective approach to achieve a clinically significant reduction in ionising radiation exposure for both patient and operator.

AB - Introduction Radiofrequency catheter ablation is the mainstay of therapy for supraventricular tachyarrhythmias. Conventional radiofrequency catheter ablation requires the use of fluoroscopy, thus exposing patients to ionising radiation. The feasibility and safety of non-fluoroscopic radiofrequency catheter ablation has been recently reported in a wide range of supraventricular tachyarrhythmias using the EnSite NavX™ mapping system. The NO-PARTY is a multi-centre, randomised controlled trial designed to test the hypothesis that catheter ablation of supraventricular tachyarrhythmias guided by the EnSite NavX™ mapping system results in a clinically significant reduction in exposure to ionising radiation compared with conventional catheter ablation. Methods The study will randomise 210 patients undergoing catheter ablation of supraventricular tachyarrhythmias to either a conventional ablation technique or one guided by the EnSite NavX™ mapping system. The primary end-point is the reduction of the radiation dose to the patient. Secondary end-points include procedural success, reduction of the radiation dose to the operator, and a cost-effectiveness analysis. In a subgroup of patients, we will also evaluate the radiobiological effectiveness of dose reduction by assessing acute chromosomal DNA damage in peripheral blood lymphocytes. Conclusions NO-PARTY will determine whether radiofrequency catheter ablation of supraventricular tachyarrhythmias guided by the EnSite NavX™ mapping system is a suitable and cost-effective approach to achieve a clinically significant reduction in ionising radiation exposure for both patient and operator.

KW - accessory pathway

KW - Atrioventricular nodal reentrant tachycardia

KW - electroanatomical mapping

KW - radiation exposure

KW - radiofrequency catheter ablation

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