Rationale and design for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study

Rulan S. Parekh, Lucy A. Meoni, Bernard G. Jaar, Stephen M. Sozio, Tariq Shafi, Gordon F. Tomaselli, Joao A. Lima, Larisa G. Tereshchenko, Michelle M. Estrella, W. H.Linda Kao

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Sudden cardiac death occurs commonly in the end-stage renal disease population receiving dialysis, with 25% dying of sudden cardiac death over 5 years. Despite this high risk, surprisingly few prospective studies have studied clinical- and dialysis-related risk factors for sudden cardiac death and arrhythmic precursors of sudden cardiac death in end-stage renal disease. Methods/Design: We present a brief summary of the risk factors for arrhythmias and sudden cardiac death in persons with end-stage renal disease as the rationale for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study, a prospective cohort study of patients recently initiated on chronic hemodialysis, with the overall goal to understand arrhythmic and sudden cardiac death risk. Participants were screened for eligibility and excluded if they already had a pacemaker or an automatic implantable cardioverter defibrillator. We describe the study aims, design, and data collection of 574 incident hemodialysis participants from the Baltimore region in Maryland, U.S.A.. Participants were recruited from 27 hemodialysis units and underwent detailed clinical, dialysis and cardiovascular evaluation at baseline and follow-up. Cardiovascular phenotyping was conducted on nondialysis days with signal averaged electrocardiogram, echocardiogram, pulse wave velocity, ankle, brachial index, and cardiac computed tomography and angiography conducted at baseline. Participants were followed annually with study visits including electrocardiogram, pulse wave velocity, and ankle brachial index up to 4 years. A biorepository of serum, plasma, DNA, RNA, and nails were collected to study genetic and serologic factors associated with disease. Discussion: Studies of modifiable risk factors for sudden cardiac death will help set the stage for clinical trials to test therapies to prevent sudden cardiac death in this high-risk population.

Original languageEnglish (US)
Article number63
JournalBMC Nephrology
Volume16
Issue number1
DOIs
StatePublished - Apr 24 2015
Externally publishedYes

Fingerprint

Sudden Cardiac Death
Chronic Kidney Failure
Renal Dialysis
Dialysis
Ankle Brachial Index
Pulse Wave Analysis
Electrocardiography
Prospective Studies
Baltimore
Implantable Defibrillators
Nails
Population
Cardiac Arrhythmias
Cohort Studies
Clinical Trials
RNA
DNA
Serum

Keywords

  • Arrhythmia
  • Dialysis
  • End stage renal disease
  • Hemodialysis
  • Mortality
  • Sudden cardiac death
  • Sudden death

ASJC Scopus subject areas

  • Nephrology

Cite this

Rationale and design for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study. / Parekh, Rulan S.; Meoni, Lucy A.; Jaar, Bernard G.; Sozio, Stephen M.; Shafi, Tariq; Tomaselli, Gordon F.; Lima, Joao A.; Tereshchenko, Larisa G.; Estrella, Michelle M.; Kao, W. H.Linda.

In: BMC Nephrology, Vol. 16, No. 1, 63, 24.04.2015.

Research output: Contribution to journalArticle

Parekh, RS, Meoni, LA, Jaar, BG, Sozio, SM, Shafi, T, Tomaselli, GF, Lima, JA, Tereshchenko, LG, Estrella, MM & Kao, WHL 2015, 'Rationale and design for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study', BMC Nephrology, vol. 16, no. 1, 63. https://doi.org/10.1186/s12882-015-0050-4
Parekh, Rulan S. ; Meoni, Lucy A. ; Jaar, Bernard G. ; Sozio, Stephen M. ; Shafi, Tariq ; Tomaselli, Gordon F. ; Lima, Joao A. ; Tereshchenko, Larisa G. ; Estrella, Michelle M. ; Kao, W. H.Linda. / Rationale and design for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study. In: BMC Nephrology. 2015 ; Vol. 16, No. 1.
@article{98aee082d6f941958bdcac72bfaf5f90,
title = "Rationale and design for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study",
abstract = "Background: Sudden cardiac death occurs commonly in the end-stage renal disease population receiving dialysis, with 25{\%} dying of sudden cardiac death over 5 years. Despite this high risk, surprisingly few prospective studies have studied clinical- and dialysis-related risk factors for sudden cardiac death and arrhythmic precursors of sudden cardiac death in end-stage renal disease. Methods/Design: We present a brief summary of the risk factors for arrhythmias and sudden cardiac death in persons with end-stage renal disease as the rationale for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study, a prospective cohort study of patients recently initiated on chronic hemodialysis, with the overall goal to understand arrhythmic and sudden cardiac death risk. Participants were screened for eligibility and excluded if they already had a pacemaker or an automatic implantable cardioverter defibrillator. We describe the study aims, design, and data collection of 574 incident hemodialysis participants from the Baltimore region in Maryland, U.S.A.. Participants were recruited from 27 hemodialysis units and underwent detailed clinical, dialysis and cardiovascular evaluation at baseline and follow-up. Cardiovascular phenotyping was conducted on nondialysis days with signal averaged electrocardiogram, echocardiogram, pulse wave velocity, ankle, brachial index, and cardiac computed tomography and angiography conducted at baseline. Participants were followed annually with study visits including electrocardiogram, pulse wave velocity, and ankle brachial index up to 4 years. A biorepository of serum, plasma, DNA, RNA, and nails were collected to study genetic and serologic factors associated with disease. Discussion: Studies of modifiable risk factors for sudden cardiac death will help set the stage for clinical trials to test therapies to prevent sudden cardiac death in this high-risk population.",
keywords = "Arrhythmia, Dialysis, End stage renal disease, Hemodialysis, Mortality, Sudden cardiac death, Sudden death",
author = "Parekh, {Rulan S.} and Meoni, {Lucy A.} and Jaar, {Bernard G.} and Sozio, {Stephen M.} and Tariq Shafi and Tomaselli, {Gordon F.} and Lima, {Joao A.} and Tereshchenko, {Larisa G.} and Estrella, {Michelle M.} and Kao, {W. H.Linda}",
year = "2015",
month = "4",
day = "24",
doi = "10.1186/s12882-015-0050-4",
language = "English (US)",
volume = "16",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Rationale and design for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study

AU - Parekh, Rulan S.

AU - Meoni, Lucy A.

AU - Jaar, Bernard G.

AU - Sozio, Stephen M.

AU - Shafi, Tariq

AU - Tomaselli, Gordon F.

AU - Lima, Joao A.

AU - Tereshchenko, Larisa G.

AU - Estrella, Michelle M.

AU - Kao, W. H.Linda

PY - 2015/4/24

Y1 - 2015/4/24

N2 - Background: Sudden cardiac death occurs commonly in the end-stage renal disease population receiving dialysis, with 25% dying of sudden cardiac death over 5 years. Despite this high risk, surprisingly few prospective studies have studied clinical- and dialysis-related risk factors for sudden cardiac death and arrhythmic precursors of sudden cardiac death in end-stage renal disease. Methods/Design: We present a brief summary of the risk factors for arrhythmias and sudden cardiac death in persons with end-stage renal disease as the rationale for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study, a prospective cohort study of patients recently initiated on chronic hemodialysis, with the overall goal to understand arrhythmic and sudden cardiac death risk. Participants were screened for eligibility and excluded if they already had a pacemaker or an automatic implantable cardioverter defibrillator. We describe the study aims, design, and data collection of 574 incident hemodialysis participants from the Baltimore region in Maryland, U.S.A.. Participants were recruited from 27 hemodialysis units and underwent detailed clinical, dialysis and cardiovascular evaluation at baseline and follow-up. Cardiovascular phenotyping was conducted on nondialysis days with signal averaged electrocardiogram, echocardiogram, pulse wave velocity, ankle, brachial index, and cardiac computed tomography and angiography conducted at baseline. Participants were followed annually with study visits including electrocardiogram, pulse wave velocity, and ankle brachial index up to 4 years. A biorepository of serum, plasma, DNA, RNA, and nails were collected to study genetic and serologic factors associated with disease. Discussion: Studies of modifiable risk factors for sudden cardiac death will help set the stage for clinical trials to test therapies to prevent sudden cardiac death in this high-risk population.

AB - Background: Sudden cardiac death occurs commonly in the end-stage renal disease population receiving dialysis, with 25% dying of sudden cardiac death over 5 years. Despite this high risk, surprisingly few prospective studies have studied clinical- and dialysis-related risk factors for sudden cardiac death and arrhythmic precursors of sudden cardiac death in end-stage renal disease. Methods/Design: We present a brief summary of the risk factors for arrhythmias and sudden cardiac death in persons with end-stage renal disease as the rationale for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study, a prospective cohort study of patients recently initiated on chronic hemodialysis, with the overall goal to understand arrhythmic and sudden cardiac death risk. Participants were screened for eligibility and excluded if they already had a pacemaker or an automatic implantable cardioverter defibrillator. We describe the study aims, design, and data collection of 574 incident hemodialysis participants from the Baltimore region in Maryland, U.S.A.. Participants were recruited from 27 hemodialysis units and underwent detailed clinical, dialysis and cardiovascular evaluation at baseline and follow-up. Cardiovascular phenotyping was conducted on nondialysis days with signal averaged electrocardiogram, echocardiogram, pulse wave velocity, ankle, brachial index, and cardiac computed tomography and angiography conducted at baseline. Participants were followed annually with study visits including electrocardiogram, pulse wave velocity, and ankle brachial index up to 4 years. A biorepository of serum, plasma, DNA, RNA, and nails were collected to study genetic and serologic factors associated with disease. Discussion: Studies of modifiable risk factors for sudden cardiac death will help set the stage for clinical trials to test therapies to prevent sudden cardiac death in this high-risk population.

KW - Arrhythmia

KW - Dialysis

KW - End stage renal disease

KW - Hemodialysis

KW - Mortality

KW - Sudden cardiac death

KW - Sudden death

UR - http://www.scopus.com/inward/record.url?scp=84929438995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929438995&partnerID=8YFLogxK

U2 - 10.1186/s12882-015-0050-4

DO - 10.1186/s12882-015-0050-4

M3 - Article

C2 - 25903746

AN - SCOPUS:84929438995

VL - 16

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

M1 - 63

ER -