Rapid publication a chromogranin a‐derived peptide differentially regulates the secretion of calcitonin gene products

Leonard J. Deftos, Ruth Hogue‐Angeletti, Cheryl Chalberg, Su Tu

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

We studied the regulation of the secretion of CT and CGRP by chromogranin A (CgA)‐derived peptides in a human lung tumor cell line. The amino‐terminal peptide of CgA, CgA1‐40, stimulated the secretion of CGRP and inhibited the secretion of CT; both effects occurred in a dose‐dependent manner. These studies demonstrate a differential effect of a CgA‐derived peptide on two products of the CT gene, CT itself and CGRP. CgA may be processed at its multiple dibasic sites to peptides that specifically regulate the secretion of its coresident hormones, in this case two calcitonin gene products that are present in the same secretory vesicle. This novel mechanism represents a new pathway for the control of calcium regulating hormones.

Original languageEnglish (US)
Pages (from-to)989-991
Number of pages3
JournalJournal of Bone and Mineral Research
Volume5
Issue number9
DOIs
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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