TY - JOUR
T1 - Rapid publication a chromogranin a‐derived peptide differentially regulates the secretion of calcitonin gene products
AU - Deftos, Leonard J.
AU - Hogue‐Angeletti, Ruth
AU - Chalberg, Cheryl
AU - Tu, Su
PY - 1990/9
Y1 - 1990/9
N2 - We studied the regulation of the secretion of CT and CGRP by chromogranin A (CgA)‐derived peptides in a human lung tumor cell line. The amino‐terminal peptide of CgA, CgA1‐40, stimulated the secretion of CGRP and inhibited the secretion of CT; both effects occurred in a dose‐dependent manner. These studies demonstrate a differential effect of a CgA‐derived peptide on two products of the CT gene, CT itself and CGRP. CgA may be processed at its multiple dibasic sites to peptides that specifically regulate the secretion of its coresident hormones, in this case two calcitonin gene products that are present in the same secretory vesicle. This novel mechanism represents a new pathway for the control of calcium regulating hormones.
AB - We studied the regulation of the secretion of CT and CGRP by chromogranin A (CgA)‐derived peptides in a human lung tumor cell line. The amino‐terminal peptide of CgA, CgA1‐40, stimulated the secretion of CGRP and inhibited the secretion of CT; both effects occurred in a dose‐dependent manner. These studies demonstrate a differential effect of a CgA‐derived peptide on two products of the CT gene, CT itself and CGRP. CgA may be processed at its multiple dibasic sites to peptides that specifically regulate the secretion of its coresident hormones, in this case two calcitonin gene products that are present in the same secretory vesicle. This novel mechanism represents a new pathway for the control of calcium regulating hormones.
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U2 - 10.1002/jbmr.5650050913
DO - 10.1002/jbmr.5650050913
M3 - Article
C2 - 2177955
AN - SCOPUS:0025024536
SN - 0884-0431
VL - 5
SP - 989
EP - 991
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 9
ER -