@article{e9b3df8a8466489687f2ba38bb6776d4,
title = "Randomized, double-blind, multicenter trial comparing clinafloxacin with imipenem as empirical monotherapy for febrile granulocytopenic patients",
abstract = "In a double-blind, multicenter trial, 541 febrile granulocytopenic patients were randomized to receive either intravenous (iv) clinafloxacin (200 mg every 12 h) or iv imipenem (500 mg every 6 h) as empirical monotherapy. More baseline pathogens were susceptible to clinafloxacin (259 [99%] of 262 organisms) than to imipenem (253 [95%] of 265; P = .03). Initial favorable clinical response rates for clinafloxacin (88 [32%] of 272 patients) and imipenem (89 [33%] of 269) were similar. After addition of other antimicrobial agents, overall response rates were 259 (95%) of 272 for clinafloxacin and 251 (93%) of 269 for imipenem. During the study, only 13 clinafloxacin (5%) and 18 imipenem (7%) recipients died. Both drugs were generally well tolerated. Drug-related skin rash occurred more often with clinafloxacin (11% vs. 6%; P = .07), whereas nausea (2% vs. 5%; P = .16), Clostridium-difficile-associated diarrhea (3% vs. 8%; P = .02), and seizures (0% vs. 2%; P = .06) occurred more often with imipenem. These results suggest that clinafloxacin and imipenem have similar efficacy as empirical monotherapy in febrile granulocytopenic patients.",
author = "Winston, {D. J.} and Lazarus, {H. M.} and Beveridge, {R. A.} and Hathorn, {J. W.} and R. Gucalp and R. Ramphal and Chow, {A. W.} and Ho, {W. G.} and R. Horn and R. Feld and Louie, {T. J.} and Territo, {M. C.} and Blumer, {J. L.} and Tack, {K. J.}",
note = "Funding Information: Financial support: Parke-Davis Pharmaceutical Research. Funding Information: Principal Investigator(s) (Institution): Drs. Drew J. Winston and Mary C. Territo (UCLA Medical Center); Drs. Hillard M. Lazarus and Jeffrey L. Blumer (Case Western Reserve University Hospital, Cleveland); Dr. Roy A. Beveridge (Fairfax Hospital, Falls Church, VA); Dr. James W. Hathorn (Duke University Medical Center, Durham, NC); Dr. Rasim Gucalp (Montefiore Medical Center, Bronx, NY); Dr. Reuben Ramphal (University of Florida Medical Center, Gainesville, FL); Drs. Anthony W. Chow and H. Grant Stiver (Vancouver Hospital, Vancouver, British Columbia, Canada); Dr. Winston G. Ho (St. Joseph{\textquoteright}s Hospital, Orange, CA); Drs. Ruth Horn and Hugh G. Robson (Royal Victoria Hospital, Montreal); Drs. Ronald Feld and Alison McGeer (Princess Margaret Hospital, Toronto); Drs. Thomas J. Louie, David Megran, and Ronald Read (Calgary General Hospital, Calgary, Alberta, Canada); Dr. Nigar Kirmani (Loyola University Medical Center, Maywood, IL); Dr. Julio Alberto Ramirez (Veterans Hospital, Louisville, KY); Dr. Eric J. Bow (University of Manitoba Hospital, Winnipeg, Canada); Dr. James S. Tan (Akron City Hospital, Akron, OH). Study Co-ordinator (Institution): Ann Gogesch, RN (UCLA Medical Center); Eloise Lemon, RN, Sandy Fiala, RN (Case Western Reserve University Hospital, Cleveland); Kristin Friedman, RN (Mon-tefiore Medical Center, Bronx, NY); Kenna Sleigh, RN, MSN (Vancouver Hospital, Vancouver, British Columbia, Canada); Charlene Barker, RN (Royal Victoria Hospital, Montreal); Trish Muir, RN (Calgary General Hospital, Calgary, Alberta, Canada).",
year = "2001",
doi = "10.1086/318500",
language = "English (US)",
volume = "32",
pages = "381--390",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "3",
}
