Random Positional Variation Among the Skull, Mandible, and Cervical Spine With Treatment Progression During Head-and-Neck Radiotherapy

Peter H. Ahn, Andrew I. Ahn, C. Joe Lee, Jin Shen, Ekeni Miller, Alex Lukaj, Elissa Milan, Ravindra Yaparpalvi, Shalom Kalnicki, Madhur K. Garg

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Purpose: With 54° of freedom from the skull to mandible to C7, ensuring adequate immobilization for head-and-neck radiotherapy (RT) is complex. We quantify variations in skull, mandible, and cervical spine movement between RT sessions. Methods and Materials: Twenty-three sequential head-and-neck RT patients underwent serial computed tomography. Patients underwent planned rescanning at 11, 22, and 33 fractions for a total of 93 scans. Coordinates of multiple bony elements of the skull, mandible, and cervical spine were used to calculate rotational and translational changes of bony anatomy compared with the original planning scan. Results: Mean translational and rotational variations on rescanning were negligible, but showed a wide range. Changes in scoliosis and lordosis of the cervical spine between fractions showed similar variability. There was no correlation between positional variation and fraction number and no strong correlation with weight loss or skin separation. Semi-independent rotational and translation movement of the skull in relation to the lower cervical spine was shown. Positioning variability measured by means of vector displacement was largest in the mandible and lower cervical spine. Conclusions: Although only small overall variations in position between head-and-neck RT sessions exist on average, there is significant random variation in patient positioning of the skull, mandible, and cervical spine elements. Such variation is accentuated in the mandible and lower cervical spine. These random semirigid variations in positioning of the skull and spine point to a need for improved immobilization and/or confirmation of patient positioning in RT of the head and neck.

Original languageEnglish (US)
Pages (from-to)626-633
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume73
Issue number2
DOIs
StatePublished - Feb 1 2009

Fingerprint

skull
spine
Mandible
Skull
progressions
radiation therapy
Spine
Neck
Radiotherapy
Head
positioning
Patient Positioning
Therapeutics
immobilization
Immobilization
Lordosis
anatomy
Scoliosis
planning
Weight Loss

Keywords

  • Head-and-neck tumor
  • Immobilization
  • Radiotherapy
  • Repositioning accuracy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Random Positional Variation Among the Skull, Mandible, and Cervical Spine With Treatment Progression During Head-and-Neck Radiotherapy. / Ahn, Peter H.; Ahn, Andrew I.; Lee, C. Joe; Shen, Jin; Miller, Ekeni; Lukaj, Alex; Milan, Elissa; Yaparpalvi, Ravindra; Kalnicki, Shalom; Garg, Madhur K.

In: International Journal of Radiation Oncology Biology Physics, Vol. 73, No. 2, 01.02.2009, p. 626-633.

Research output: Contribution to journalArticle

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abstract = "Purpose: With 54° of freedom from the skull to mandible to C7, ensuring adequate immobilization for head-and-neck radiotherapy (RT) is complex. We quantify variations in skull, mandible, and cervical spine movement between RT sessions. Methods and Materials: Twenty-three sequential head-and-neck RT patients underwent serial computed tomography. Patients underwent planned rescanning at 11, 22, and 33 fractions for a total of 93 scans. Coordinates of multiple bony elements of the skull, mandible, and cervical spine were used to calculate rotational and translational changes of bony anatomy compared with the original planning scan. Results: Mean translational and rotational variations on rescanning were negligible, but showed a wide range. Changes in scoliosis and lordosis of the cervical spine between fractions showed similar variability. There was no correlation between positional variation and fraction number and no strong correlation with weight loss or skin separation. Semi-independent rotational and translation movement of the skull in relation to the lower cervical spine was shown. Positioning variability measured by means of vector displacement was largest in the mandible and lower cervical spine. Conclusions: Although only small overall variations in position between head-and-neck RT sessions exist on average, there is significant random variation in patient positioning of the skull, mandible, and cervical spine elements. Such variation is accentuated in the mandible and lower cervical spine. These random semirigid variations in positioning of the skull and spine point to a need for improved immobilization and/or confirmation of patient positioning in RT of the head and neck.",
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AU - Lee, C. Joe

AU - Shen, Jin

AU - Miller, Ekeni

AU - Lukaj, Alex

AU - Milan, Elissa

AU - Yaparpalvi, Ravindra

AU - Kalnicki, Shalom

AU - Garg, Madhur K.

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