Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function

Medicine & Life Sciences

• Proton-Coupled Folate Transporter 100%
• Hereditary Folate Malabsorption 90%
• Mutagenesis 53%
• Cluster Analysis 48%
• Mutation 30%
• Loss of Function Mutation 20%
• INDEL Mutation 14%
• Initiator Codon 11%
• Genes 11%
• Folic Acid 9%
• Codon 8%
• Cell Membrane 6%
• Polymerase Chain Reaction 5%

Chemical Compounds

• Folate 65%
• Mutation 46%
• Disorder 10%
• Substitution Reaction 7%
• Plasma 3%