Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study

Nitin Ohri; Laura A. Dawson; Sunil Krishnan; Jinsil Seong; Jason C. Cheng; Shiv K. Sarin; Milan Kinkhabwala; Mansoor M. Ahmed; Bhadrasain Vikram; C. Norman Coleman; Chandan Guha

doi:10.1093/jnci/djw133

Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study

Nitin Ohri, Laura A. Dawson, Sunil Krishnan, Jinsil Seong, Jason C. Cheng, Shiv K. Sarin, Milan Kinkhabwala, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Chandan Guha

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of the National Cancer Institute's Radiation Research Program, we suggest how RT should be implemented in the management of HCC and identify future directions for the study of RT in HCC.

Original language	English (US)
Article number	djw133
Journal	Journal of the National Cancer Institute
Volume	108
Issue number	9
DOIs	https://doi.org/10.1093/jnci/djw133
State	Published - Sep 1 2016

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jnci/djw133

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title = "Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study",

abstract = "Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of the National Cancer Institute's Radiation Research Program, we suggest how RT should be implemented in the management of HCC and identify future directions for the study of RT in HCC.",

author = "Nitin Ohri and Dawson, {Laura A.} and Sunil Krishnan and Jinsil Seong and Cheng, {Jason C.} and Sarin, {Shiv K.} and Milan Kinkhabwala and Ahmed, {Mansoor M.} and Bhadrasain Vikram and Coleman, {C. Norman} and Chandan Guha",

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month = sep,

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doi = "10.1093/jnci/djw133",

language = "English (US)",

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T1 - Radiotherapy for Hepatocellular Carcinoma

T2 - New Indications and Directions for Future Study

AU - Ohri, Nitin

AU - Dawson, Laura A.

AU - Krishnan, Sunil

AU - Seong, Jinsil

AU - Cheng, Jason C.

AU - Sarin, Shiv K.

AU - Kinkhabwala, Milan

AU - Ahmed, Mansoor M.

AU - Vikram, Bhadrasain

AU - Coleman, C. Norman

AU - Guha, Chandan

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of the National Cancer Institute's Radiation Research Program, we suggest how RT should be implemented in the management of HCC and identify future directions for the study of RT in HCC.

AB - Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of the National Cancer Institute's Radiation Research Program, we suggest how RT should be implemented in the management of HCC and identify future directions for the study of RT in HCC.

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DO - 10.1093/jnci/djw133

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VL - 108

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

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Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study

Abstract

ASJC Scopus subject areas

UN SDGs

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