Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study

Nitin Ohri, Laura A. Dawson, Sunil Krishnan, Jinsil Seong, Jason C. Cheng, Shiv K. Sarin, Milan Kinkhabwala, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Chandan Guha

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of the National Cancer Institute's Radiation Research Program, we suggest how RT should be implemented in the management of HCC and identify future directions for the study of RT in HCC.

Original languageEnglish (US)
Article numberdjw133
JournalJournal of the National Cancer Institute
Volume108
Issue number9
DOIs
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

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    Ohri, N., Dawson, L. A., Krishnan, S., Seong, J., Cheng, J. C., Sarin, S. K., Kinkhabwala, M., Ahmed, M. M., Vikram, B., Coleman, C. N., & Guha, C. (2016). Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study. Journal of the National Cancer Institute, 108(9), [djw133]. https://doi.org/10.1093/jnci/djw133