Radiologic Features of World Trade Center–related Sarcoidosis in Exposed NYC Fire Department Rescue Workers

Francis Girvin, Rachel Zeig-Owens, Deepti Gupta, Theresa Schwartz, Yang Liu, Michael D. Weiden, David J. Prezant, David P. Naidich

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PURPOSE:: An increased incidence of sarcoidosis has been demonstrated in firefighters, supporting the concern that occupational/environmental exposure may pose an etiologic risk factor. This incidence increased further after September 11, 2001 following exposure to World Trade Center (WTC) dust and gases. We review computed tomography (CT) features in this population, comparing the range of findings and physiological correlates with those typically reported in unexposed individuals with pulmonary sarcoidosis. MATERIALS AND METHODS:: With CT imaging we retrospectively identified 46 patients with WTC-related sarcoidosis, between March 18, 2002 and April 5, 2014. Scans were independently reviewed by 2 dedicated thoracic radiologists and assessed for disease patterns and correlation with pulmonary functions. RESULTS:: The majority (37/46; 80%) had symmetric mediastinal and hilar lymphadenopathy. Similarly, most (38/46; 83%) had perilymphatic nodules. Foci of ill-defined ground glass attenuation were present in 6 (13%). Coalescent nodularity was present in 15 (33%). Only 3 (7%) had parenchymal reticulation. A mixed pattern of lung findings was present in 21 (46%). When all forms of parenchymal disease were scored by zonal distribution, 21 (46%) had parenchymal disease predominantly involving mid and upper lungs; 11/46 (24%) had a random distribution without zonal predominance; 6/46 (13%) demonstrated atypical lower zone predominance. Whereas 15/46 (33%) had obstructive airways disease on pulmonary function tests, there were no CT findings that were predictive of obstructive airways disease. CONCLUSIONS:: The majority of cases of WTC-related sarcoidosis demonstrated typical radiographic appearances of sarcoidosis, with symmetric hilar and mediastinal lymphadenopathy and mid to upper lung perilymphatic nodules; these findings were consistent with other previously reported cases of sarcoid-like granulomatous disease in association with various alternate underlying etiologies. There was no correlation between disease patterns or extent on CT and pulmonary function testing, likely at least in part due to the overall mild extent of disease in this population.

Original languageEnglish (US)
JournalJournal of Thoracic Imaging
DOIs
StateAccepted/In press - Jul 20 2016

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Sarcoidosis
Lung
Tomography
Firefighters
Pulmonary Sarcoidosis
Respiratory Function Tests
Incidence
Environmental Exposure
Occupational Exposure
Dust
Population
Glass
Thorax
Gases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pulmonary and Respiratory Medicine

Cite this

Girvin, F., Zeig-Owens, R., Gupta, D., Schwartz, T., Liu, Y., Weiden, M. D., ... Naidich, D. P. (Accepted/In press). Radiologic Features of World Trade Center–related Sarcoidosis in Exposed NYC Fire Department Rescue Workers. Journal of Thoracic Imaging. https://doi.org/10.1097/RTI.0000000000000230

Radiologic Features of World Trade Center–related Sarcoidosis in Exposed NYC Fire Department Rescue Workers. / Girvin, Francis; Zeig-Owens, Rachel; Gupta, Deepti; Schwartz, Theresa; Liu, Yang; Weiden, Michael D.; Prezant, David J.; Naidich, David P.

In: Journal of Thoracic Imaging, 20.07.2016.

Research output: Contribution to journalArticle

Girvin, Francis ; Zeig-Owens, Rachel ; Gupta, Deepti ; Schwartz, Theresa ; Liu, Yang ; Weiden, Michael D. ; Prezant, David J. ; Naidich, David P. / Radiologic Features of World Trade Center–related Sarcoidosis in Exposed NYC Fire Department Rescue Workers. In: Journal of Thoracic Imaging. 2016.
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abstract = "PURPOSE:: An increased incidence of sarcoidosis has been demonstrated in firefighters, supporting the concern that occupational/environmental exposure may pose an etiologic risk factor. This incidence increased further after September 11, 2001 following exposure to World Trade Center (WTC) dust and gases. We review computed tomography (CT) features in this population, comparing the range of findings and physiological correlates with those typically reported in unexposed individuals with pulmonary sarcoidosis. MATERIALS AND METHODS:: With CT imaging we retrospectively identified 46 patients with WTC-related sarcoidosis, between March 18, 2002 and April 5, 2014. Scans were independently reviewed by 2 dedicated thoracic radiologists and assessed for disease patterns and correlation with pulmonary functions. RESULTS:: The majority (37/46; 80{\%}) had symmetric mediastinal and hilar lymphadenopathy. Similarly, most (38/46; 83{\%}) had perilymphatic nodules. Foci of ill-defined ground glass attenuation were present in 6 (13{\%}). Coalescent nodularity was present in 15 (33{\%}). Only 3 (7{\%}) had parenchymal reticulation. A mixed pattern of lung findings was present in 21 (46{\%}). When all forms of parenchymal disease were scored by zonal distribution, 21 (46{\%}) had parenchymal disease predominantly involving mid and upper lungs; 11/46 (24{\%}) had a random distribution without zonal predominance; 6/46 (13{\%}) demonstrated atypical lower zone predominance. Whereas 15/46 (33{\%}) had obstructive airways disease on pulmonary function tests, there were no CT findings that were predictive of obstructive airways disease. CONCLUSIONS:: The majority of cases of WTC-related sarcoidosis demonstrated typical radiographic appearances of sarcoidosis, with symmetric hilar and mediastinal lymphadenopathy and mid to upper lung perilymphatic nodules; these findings were consistent with other previously reported cases of sarcoid-like granulomatous disease in association with various alternate underlying etiologies. There was no correlation between disease patterns or extent on CT and pulmonary function testing, likely at least in part due to the overall mild extent of disease in this population.",
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AU - Weiden, Michael D.

AU - Prezant, David J.

AU - Naidich, David P.

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AB - PURPOSE:: An increased incidence of sarcoidosis has been demonstrated in firefighters, supporting the concern that occupational/environmental exposure may pose an etiologic risk factor. This incidence increased further after September 11, 2001 following exposure to World Trade Center (WTC) dust and gases. We review computed tomography (CT) features in this population, comparing the range of findings and physiological correlates with those typically reported in unexposed individuals with pulmonary sarcoidosis. MATERIALS AND METHODS:: With CT imaging we retrospectively identified 46 patients with WTC-related sarcoidosis, between March 18, 2002 and April 5, 2014. Scans were independently reviewed by 2 dedicated thoracic radiologists and assessed for disease patterns and correlation with pulmonary functions. RESULTS:: The majority (37/46; 80%) had symmetric mediastinal and hilar lymphadenopathy. Similarly, most (38/46; 83%) had perilymphatic nodules. Foci of ill-defined ground glass attenuation were present in 6 (13%). Coalescent nodularity was present in 15 (33%). Only 3 (7%) had parenchymal reticulation. A mixed pattern of lung findings was present in 21 (46%). When all forms of parenchymal disease were scored by zonal distribution, 21 (46%) had parenchymal disease predominantly involving mid and upper lungs; 11/46 (24%) had a random distribution without zonal predominance; 6/46 (13%) demonstrated atypical lower zone predominance. Whereas 15/46 (33%) had obstructive airways disease on pulmonary function tests, there were no CT findings that were predictive of obstructive airways disease. CONCLUSIONS:: The majority of cases of WTC-related sarcoidosis demonstrated typical radiographic appearances of sarcoidosis, with symmetric hilar and mediastinal lymphadenopathy and mid to upper lung perilymphatic nodules; these findings were consistent with other previously reported cases of sarcoid-like granulomatous disease in association with various alternate underlying etiologies. There was no correlation between disease patterns or extent on CT and pulmonary function testing, likely at least in part due to the overall mild extent of disease in this population.

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