TY - JOUR
T1 - Radiolabeled antibodies for therapy of infectious diseases
AU - Dadachova, Ekaterina
AU - Casadevall, Arturo
N1 - Publisher Copyright:
© 2014 American Society for Microbiology. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Novel approaches to the treatment of infectious diseases are urgently needed. This need has resulted in renewing the interest in antibodies for therapy of infectious diseases. Radioimmunotherapy (RIT) is a cancer treatment modality that utilizes radiolabeled monoclonal antibodies. During the last decade we have translated RIT into the field of experimental fungal, bacterial, and HIV infections. In addition, successful proof of principle experiments with radiolabeled pan-antibodies that bind to antigens shared by major pathogenic fungi have been performed in vitro. The armamentarium of pan-antibodies would result in reducing our dependence on microorganism-specific antibodies and thus would speed up the development of RIT for infections. We believe that the time is ripe for deploying RIT in the clinic to combat infectious diseases.
AB - Novel approaches to the treatment of infectious diseases are urgently needed. This need has resulted in renewing the interest in antibodies for therapy of infectious diseases. Radioimmunotherapy (RIT) is a cancer treatment modality that utilizes radiolabeled monoclonal antibodies. During the last decade we have translated RIT into the field of experimental fungal, bacterial, and HIV infections. In addition, successful proof of principle experiments with radiolabeled pan-antibodies that bind to antigens shared by major pathogenic fungi have been performed in vitro. The armamentarium of pan-antibodies would result in reducing our dependence on microorganism-specific antibodies and thus would speed up the development of RIT for infections. We believe that the time is ripe for deploying RIT in the clinic to combat infectious diseases.
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U2 - 10.1128/microbiolspec.aid-0023-2014
DO - 10.1128/microbiolspec.aid-0023-2014
M3 - Article
AN - SCOPUS:84957428369
SN - 2165-0497
VL - 2
JO - Microbiology Spectrum
JF - Microbiology Spectrum
IS - 6
M1 - AID-0023-2014
ER -