Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection

Ruth A. Bryan, Zewei Jiang, Robertha C. Howell, Alfred Morgenstern, Frank Bruchertseifer, Arturo Casadeval, Ekaterina Dadachova

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/ Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with 213Bi-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. 213Bi-18B7 treatment almost completely eliminated colonyforming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalJournal of Infectious Diseases
Volume202
Issue number4
DOIs
StatePublished - Aug 15 2010
Externally publishedYes

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Radioimmunotherapy
Cryptococcus neoformans
Amphotericin B
Infection
Therapeutics
Stem Cells
Lung
Antibodies
Brain

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Bryan, R. A., Jiang, Z., Howell, R. C., Morgenstern, A., Bruchertseifer, F., Casadeval, A., & Dadachova, E. (2010). Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection. Journal of Infectious Diseases, 202(4), 633-637. https://doi.org/10.1086/654813

Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection. / Bryan, Ruth A.; Jiang, Zewei; Howell, Robertha C.; Morgenstern, Alfred; Bruchertseifer, Frank; Casadeval, Arturo; Dadachova, Ekaterina.

In: Journal of Infectious Diseases, Vol. 202, No. 4, 15.08.2010, p. 633-637.

Research output: Contribution to journalArticle

Bryan, RA, Jiang, Z, Howell, RC, Morgenstern, A, Bruchertseifer, F, Casadeval, A & Dadachova, E 2010, 'Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection', Journal of Infectious Diseases, vol. 202, no. 4, pp. 633-637. https://doi.org/10.1086/654813
Bryan RA, Jiang Z, Howell RC, Morgenstern A, Bruchertseifer F, Casadeval A et al. Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection. Journal of Infectious Diseases. 2010 Aug 15;202(4):633-637. https://doi.org/10.1086/654813
Bryan, Ruth A. ; Jiang, Zewei ; Howell, Robertha C. ; Morgenstern, Alfred ; Bruchertseifer, Frank ; Casadeval, Arturo ; Dadachova, Ekaterina. / Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection. In: Journal of Infectious Diseases. 2010 ; Vol. 202, No. 4. pp. 633-637.
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