Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection

Ruth A. Bryan, Zewei Jiang, Robertha C. Howell, Alfred Morgenstern, Frank Bruchertseifer, Arturo Casadevall, Ekaterina Dadachova

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/ Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with 213Bi-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. 213Bi-18B7 treatment almost completely eliminated colonyforming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalJournal of Infectious Diseases
Volume202
Issue number4
DOIs
StatePublished - Aug 15 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection'. Together they form a unique fingerprint.

  • Cite this

    Bryan, R. A., Jiang, Z., Howell, R. C., Morgenstern, A., Bruchertseifer, F., Casadevall, A., & Dadachova, E. (2010). Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection. Journal of Infectious Diseases, 202(4), 633-637. https://doi.org/10.1086/654813