Radioimmunotherapy is effective against high-inoculum cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells

Ruth A. Bryan, Zewei Jiang, Xianchun Huang, Alfred Morgenstern, Frank Bruchertseifer, Rani Sellers, Arturo Casadevall, Ekaterina Dadachova

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.

Original languageEnglish (US)
Pages (from-to)1679-1682
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number4
DOIs
StatePublished - Apr 2009

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Radioimmunotherapy
Cryptococcus neoformans
Radiation
Infection
Phenotype
Mortality
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Radioimmunotherapy is effective against high-inoculum cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells. / Bryan, Ruth A.; Jiang, Zewei; Huang, Xianchun; Morgenstern, Alfred; Bruchertseifer, Frank; Sellers, Rani; Casadevall, Arturo; Dadachova, Ekaterina.

In: Antimicrobial Agents and Chemotherapy, Vol. 53, No. 4, 04.2009, p. 1679-1682.

Research output: Contribution to journalArticle

Bryan, Ruth A. ; Jiang, Zewei ; Huang, Xianchun ; Morgenstern, Alfred ; Bruchertseifer, Frank ; Sellers, Rani ; Casadevall, Arturo ; Dadachova, Ekaterina. / Radioimmunotherapy is effective against high-inoculum cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells. In: Antimicrobial Agents and Chemotherapy. 2009 ; Vol. 53, No. 4. pp. 1679-1682.
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