Radioimmunotherapy is effective against high-inoculum cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells

Ruth A. Bryan, Zewei Jiang, Xianchun Huang, Alfred Morgenstern, Frank Bruchertseifer, Rani Sellers, Arturo Casadevall, Ekaterina Dadachova

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.

Original languageEnglish (US)
Pages (from-to)1679-1682
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume53
Issue number4
DOIs
StatePublished - Apr 1 2009

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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