Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans

Ruth A. Bryan, Xianchun Huang, Alfred Morgenstern, Frank Bruchertseifer, Arturo Casadevall, Ekaterina Dadachova

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We evaluated the clonogenic survival, membrane permeability, metabolic activity (XTT reduction), and apoptosis (FLICA binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody. We found that gamma, beta, and alpha radiation affected cells through different pathways.

Original languageEnglish (US)
Pages (from-to)2232-2235
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Beta Particles
Alpha Particles
Cryptococcus neoformans
Gamma Rays
Fungal Capsules
Antibodies
Permeability
Apoptosis
Membranes

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans. / Bryan, Ruth A.; Huang, Xianchun; Morgenstern, Alfred; Bruchertseifer, Frank; Casadevall, Arturo; Dadachova, Ekaterina.

In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 6, 06.2008, p. 2232-2235.

Research output: Contribution to journalArticle

Bryan, Ruth A. ; Huang, Xianchun ; Morgenstern, Alfred ; Bruchertseifer, Frank ; Casadevall, Arturo ; Dadachova, Ekaterina. / Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans. In: Antimicrobial Agents and Chemotherapy. 2008 ; Vol. 52, No. 6. pp. 2232-2235.
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