TY - JOUR
T1 - Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans
AU - Bryan, Ruth A.
AU - Huang, Xianchun
AU - Morgenstern, Alfred
AU - Bruchertseifer, Frank
AU - Casadevall, Arturo
AU - Dadachova, Ekaterina
PY - 2008/6
Y1 - 2008/6
N2 - We evaluated the clonogenic survival, membrane permeability, metabolic activity (XTT reduction), and apoptosis (FLICA binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody. We found that gamma, beta, and alpha radiation affected cells through different pathways.
AB - We evaluated the clonogenic survival, membrane permeability, metabolic activity (XTT reduction), and apoptosis (FLICA binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody. We found that gamma, beta, and alpha radiation affected cells through different pathways.
UR - http://www.scopus.com/inward/record.url?scp=44449126151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44449126151&partnerID=8YFLogxK
U2 - 10.1128/AAC.01245-07
DO - 10.1128/AAC.01245-07
M3 - Article
C2 - 18378712
AN - SCOPUS:44449126151
SN - 0066-4804
VL - 52
SP - 2232
EP - 2235
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 6
ER -
