Radiofrequency energy delivery to the lower esophageal sphincter reduces esophageal acid exposure and improves GERD symptoms: A systematic review and meta-analysis

Kyle A. Perry, Ambar Banerjee, W. Scott Melvin

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Purpose: Studies of endoscopic application of radiofrequency energy to the lower esophageal sphincter for gastroesophageal reflux control have produced conflicting reports of its effectiveness. This study aimed to conduct a meta-analysis of randomized controlled trials and cohort studies to assess the impact of this treatment. Methods: Twenty studies were included. Outcomes analyzed included gastroesophageal reflux disease (GERD) symptom assessment, quality of life, esophageal pH, and esophageal manometry. Results: A total of 1441 patients from 18 studies were included. Radiofrequency treatment improved heartburn scores (P = 0.001), and produced improvements in quality of life as measured by GERD-health-related quality-of-life scale (P = 0.001) and quality of life in reflux and dyspepsia score (P = 0.001). Esophageal acid exposure decreased from a preprocedure Johnson-DeMeester score of 44.4 to 28.5 (P = 0.007). Conclusions: Radiofrequency ablation of the lower esophageal sphincter produces significant improvement in reflux symptoms and may represent an alternative to medical treatment and surgical fundoplication in select patients.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalSurgical Laparoscopy, Endoscopy and Percutaneous Techniques
Volume22
Issue number4
DOIs
StatePublished - Aug 2012
Externally publishedYes

Fingerprint

Lower Esophageal Sphincter
Gastroesophageal Reflux
Meta-Analysis
Quality of Life
Acids
Heartburn
Fundoplication
Symptom Assessment
Dyspepsia
Manometry
Cohort Studies
Therapeutics
Randomized Controlled Trials

Keywords

  • gastroesophageal reflux disease
  • GERD
  • radiofrequency

ASJC Scopus subject areas

  • Surgery

Cite this

@article{a9cf347495934b66ae612ae65f00de60,
title = "Radiofrequency energy delivery to the lower esophageal sphincter reduces esophageal acid exposure and improves GERD symptoms: A systematic review and meta-analysis",
abstract = "Purpose: Studies of endoscopic application of radiofrequency energy to the lower esophageal sphincter for gastroesophageal reflux control have produced conflicting reports of its effectiveness. This study aimed to conduct a meta-analysis of randomized controlled trials and cohort studies to assess the impact of this treatment. Methods: Twenty studies were included. Outcomes analyzed included gastroesophageal reflux disease (GERD) symptom assessment, quality of life, esophageal pH, and esophageal manometry. Results: A total of 1441 patients from 18 studies were included. Radiofrequency treatment improved heartburn scores (P = 0.001), and produced improvements in quality of life as measured by GERD-health-related quality-of-life scale (P = 0.001) and quality of life in reflux and dyspepsia score (P = 0.001). Esophageal acid exposure decreased from a preprocedure Johnson-DeMeester score of 44.4 to 28.5 (P = 0.007). Conclusions: Radiofrequency ablation of the lower esophageal sphincter produces significant improvement in reflux symptoms and may represent an alternative to medical treatment and surgical fundoplication in select patients.",
keywords = "gastroesophageal reflux disease, GERD, radiofrequency",
author = "Perry, {Kyle A.} and Ambar Banerjee and Melvin, {W. Scott}",
year = "2012",
month = "8",
doi = "10.1097/SLE.0b013e3182582e92",
language = "English (US)",
volume = "22",
pages = "283--288",
journal = "Surgical Laparoscopy and Endoscopy",
issn = "1530-4515",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Radiofrequency energy delivery to the lower esophageal sphincter reduces esophageal acid exposure and improves GERD symptoms

T2 - A systematic review and meta-analysis

AU - Perry, Kyle A.

AU - Banerjee, Ambar

AU - Melvin, W. Scott

PY - 2012/8

Y1 - 2012/8

N2 - Purpose: Studies of endoscopic application of radiofrequency energy to the lower esophageal sphincter for gastroesophageal reflux control have produced conflicting reports of its effectiveness. This study aimed to conduct a meta-analysis of randomized controlled trials and cohort studies to assess the impact of this treatment. Methods: Twenty studies were included. Outcomes analyzed included gastroesophageal reflux disease (GERD) symptom assessment, quality of life, esophageal pH, and esophageal manometry. Results: A total of 1441 patients from 18 studies were included. Radiofrequency treatment improved heartburn scores (P = 0.001), and produced improvements in quality of life as measured by GERD-health-related quality-of-life scale (P = 0.001) and quality of life in reflux and dyspepsia score (P = 0.001). Esophageal acid exposure decreased from a preprocedure Johnson-DeMeester score of 44.4 to 28.5 (P = 0.007). Conclusions: Radiofrequency ablation of the lower esophageal sphincter produces significant improvement in reflux symptoms and may represent an alternative to medical treatment and surgical fundoplication in select patients.

AB - Purpose: Studies of endoscopic application of radiofrequency energy to the lower esophageal sphincter for gastroesophageal reflux control have produced conflicting reports of its effectiveness. This study aimed to conduct a meta-analysis of randomized controlled trials and cohort studies to assess the impact of this treatment. Methods: Twenty studies were included. Outcomes analyzed included gastroesophageal reflux disease (GERD) symptom assessment, quality of life, esophageal pH, and esophageal manometry. Results: A total of 1441 patients from 18 studies were included. Radiofrequency treatment improved heartburn scores (P = 0.001), and produced improvements in quality of life as measured by GERD-health-related quality-of-life scale (P = 0.001) and quality of life in reflux and dyspepsia score (P = 0.001). Esophageal acid exposure decreased from a preprocedure Johnson-DeMeester score of 44.4 to 28.5 (P = 0.007). Conclusions: Radiofrequency ablation of the lower esophageal sphincter produces significant improvement in reflux symptoms and may represent an alternative to medical treatment and surgical fundoplication in select patients.

KW - gastroesophageal reflux disease

KW - GERD

KW - radiofrequency

UR - http://www.scopus.com/inward/record.url?scp=84865515120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865515120&partnerID=8YFLogxK

U2 - 10.1097/SLE.0b013e3182582e92

DO - 10.1097/SLE.0b013e3182582e92

M3 - Article

C2 - 22874675

AN - SCOPUS:84865515120

VL - 22

SP - 283

EP - 288

JO - Surgical Laparoscopy and Endoscopy

JF - Surgical Laparoscopy and Endoscopy

SN - 1530-4515

IS - 4

ER -