TY - JOUR
T1 - Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy
T2 - Safety and feasibility
AU - Santangeli, Pasquale
AU - Di Biase, Luigi
AU - Lakkireddy, Dhanunjay
AU - Burkhardt, J. David
AU - Pillarisetti, Jayasree
AU - Michowitz, Yoav
AU - Sanchez, Javier E.
AU - Horton, Rodney
AU - Mohanty, Prasant
AU - Gallinghouse, G. Joseph
AU - Dello Russo, Antonio
AU - Casella, Michela
AU - Pelargonio, Gemma
AU - Santarelli, Pietro
AU - Verma, Atul
AU - Narasimhan, Calambur
AU - Shivkumar, Kalyanam
AU - Natale, Andrea
PY - 2010
Y1 - 2010
N2 - Background: Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective: The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods: Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results: Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion: Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.
AB - Background: Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective: The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods: Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results: Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion: Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.
KW - Catheter ablation
KW - Hypertrophic cardiomyopathy
KW - Outcomes
KW - Ventricular tachycardia
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U2 - 10.1016/j.hrthm.2010.05.022
DO - 10.1016/j.hrthm.2010.05.022
M3 - Article
C2 - 20493276
AN - SCOPUS:77956855865
SN - 1547-5271
VL - 7
SP - 1036
EP - 1042
JO - Heart Rhythm
JF - Heart Rhythm
IS - 8
ER -