Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: Safety and feasibility

Pasquale Santangeli, Luigi Di Biase, Dhanunjay Lakkireddy, J. David Burkhardt, Jayasree Pillarisetti, Yoav Michowitz, Javier E. Sanchez, Rodney Horton, Prasant Mohanty, G. Joseph Gallinghouse, Antonio Dello Russo, Michela Casella, Gemma Pelargonio, Pietro Santarelli, Atul Verma, Calambur Narasimhan, Kalyanam Shivkumar, Andrea Natale

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background: Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective: The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods: Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results: Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion: Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.

Original languageEnglish (US)
Pages (from-to)1036-1042
Number of pages7
JournalHeart Rhythm
Volume7
Issue number8
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Catheter Ablation
Hypertrophic Cardiomyopathy
Cardiac Arrhythmias
Safety
Ventricular Tachycardia
Therapeutics
Catheters

Keywords

  • Catheter ablation
  • Hypertrophic cardiomyopathy
  • Outcomes
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy : Safety and feasibility. / Santangeli, Pasquale; Di Biase, Luigi; Lakkireddy, Dhanunjay; Burkhardt, J. David; Pillarisetti, Jayasree; Michowitz, Yoav; Sanchez, Javier E.; Horton, Rodney; Mohanty, Prasant; Gallinghouse, G. Joseph; Dello Russo, Antonio; Casella, Michela; Pelargonio, Gemma; Santarelli, Pietro; Verma, Atul; Narasimhan, Calambur; Shivkumar, Kalyanam; Natale, Andrea.

In: Heart Rhythm, Vol. 7, No. 8, 2010, p. 1036-1042.

Research output: Contribution to journalArticle

Santangeli, P, Di Biase, L, Lakkireddy, D, Burkhardt, JD, Pillarisetti, J, Michowitz, Y, Sanchez, JE, Horton, R, Mohanty, P, Gallinghouse, GJ, Dello Russo, A, Casella, M, Pelargonio, G, Santarelli, P, Verma, A, Narasimhan, C, Shivkumar, K & Natale, A 2010, 'Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: Safety and feasibility', Heart Rhythm, vol. 7, no. 8, pp. 1036-1042. https://doi.org/10.1016/j.hrthm.2010.05.022
Santangeli, Pasquale ; Di Biase, Luigi ; Lakkireddy, Dhanunjay ; Burkhardt, J. David ; Pillarisetti, Jayasree ; Michowitz, Yoav ; Sanchez, Javier E. ; Horton, Rodney ; Mohanty, Prasant ; Gallinghouse, G. Joseph ; Dello Russo, Antonio ; Casella, Michela ; Pelargonio, Gemma ; Santarelli, Pietro ; Verma, Atul ; Narasimhan, Calambur ; Shivkumar, Kalyanam ; Natale, Andrea. / Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy : Safety and feasibility. In: Heart Rhythm. 2010 ; Vol. 7, No. 8. pp. 1036-1042.
@article{1bd513c79df44ae09b6a4603446247a0,
title = "Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: Safety and feasibility",
abstract = "Background: Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective: The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods: Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results: Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3{\%} ± 9.8{\%}. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73{\%}. No major complication was observed during and after the procedures in all patients. Conclusion: Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.",
keywords = "Catheter ablation, Hypertrophic cardiomyopathy, Outcomes, Ventricular tachycardia",
author = "Pasquale Santangeli and {Di Biase}, Luigi and Dhanunjay Lakkireddy and Burkhardt, {J. David} and Jayasree Pillarisetti and Yoav Michowitz and Sanchez, {Javier E.} and Rodney Horton and Prasant Mohanty and Gallinghouse, {G. Joseph} and {Dello Russo}, Antonio and Michela Casella and Gemma Pelargonio and Pietro Santarelli and Atul Verma and Calambur Narasimhan and Kalyanam Shivkumar and Andrea Natale",
year = "2010",
doi = "10.1016/j.hrthm.2010.05.022",
language = "English (US)",
volume = "7",
pages = "1036--1042",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "8",

}

TY - JOUR

T1 - Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy

T2 - Safety and feasibility

AU - Santangeli, Pasquale

AU - Di Biase, Luigi

AU - Lakkireddy, Dhanunjay

AU - Burkhardt, J. David

AU - Pillarisetti, Jayasree

AU - Michowitz, Yoav

AU - Sanchez, Javier E.

AU - Horton, Rodney

AU - Mohanty, Prasant

AU - Gallinghouse, G. Joseph

AU - Dello Russo, Antonio

AU - Casella, Michela

AU - Pelargonio, Gemma

AU - Santarelli, Pietro

AU - Verma, Atul

AU - Narasimhan, Calambur

AU - Shivkumar, Kalyanam

AU - Natale, Andrea

PY - 2010

Y1 - 2010

N2 - Background: Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective: The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods: Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results: Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion: Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.

AB - Background: Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective: The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods: Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results: Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion: Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.

KW - Catheter ablation

KW - Hypertrophic cardiomyopathy

KW - Outcomes

KW - Ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=77956855865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956855865&partnerID=8YFLogxK

U2 - 10.1016/j.hrthm.2010.05.022

DO - 10.1016/j.hrthm.2010.05.022

M3 - Article

C2 - 20493276

AN - SCOPUS:77956855865

VL - 7

SP - 1036

EP - 1042

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 8

ER -